PURPOSE OF REVIEW: Allergies are a global health problem with rapidly increasing prevalence but still lacking pathogenetic knowledge or optimal treatment. The objective is to add to the conventional thinking that allergies are caused by overactive, mainly T-cell-mediated, immunological responses and thus to raise the putative role of altered epithelial functions. RECENT FINDINGS: Birch pollen allergen was rapidly and actively transported through the respiratory epithelium via caveolar-dependent mechanisms only in patients allergic to birch pollen but not their healthy controls. Transcriptomic analyses showed that whereas healthy individuals raised a strong epithelial response after intranasal allergen challenge, the allergic patients had a reduced response. Thus allergies could also be due to hyporeactive responses on the epithelial level. SUMMARY: Epithelium has emerged as an active and complex organ with mechanical, biochemical and immunological functions. The increasing awareness that epithelium interacts actively with allergens might provide new targets for the prevention and management of allergy.
PURPOSE OF REVIEW: Allergies are a global health problem with rapidly increasing prevalence but still lacking pathogenetic knowledge or optimal treatment. The objective is to add to the conventional thinking that allergies are caused by overactive, mainly T-cell-mediated, immunological responses and thus to raise the putative role of altered epithelial functions. RECENT FINDINGS: Birch pollen allergen was rapidly and actively transported through the respiratory epithelium via caveolar-dependent mechanisms only in patientsallergic to birch pollen but not their healthy controls. Transcriptomic analyses showed that whereas healthy individuals raised a strong epithelial response after intranasal allergen challenge, the allergicpatients had a reduced response. Thus allergies could also be due to hyporeactive responses on the epithelial level. SUMMARY: Epithelium has emerged as an active and complex organ with mechanical, biochemical and immunological functions. The increasing awareness that epithelium interacts actively with allergens might provide new targets for the prevention and management of allergy.
Authors: Sarah K Wise; Sandra Y Lin; Elina Toskala; Richard R Orlandi; Cezmi A Akdis; Jeremiah A Alt; Antoine Azar; Fuad M Baroody; Claus Bachert; G Walter Canonica; Thomas Chacko; Cemal Cingi; Giorgio Ciprandi; Jacquelynne Corey; Linda S Cox; Peter Socrates Creticos; Adnan Custovic; Cecelia Damask; Adam DeConde; John M DelGaudio; Charles S Ebert; Jean Anderson Eloy; Carrie E Flanagan; Wytske J Fokkens; Christine Franzese; Jan Gosepath; Ashleigh Halderman; Robert G Hamilton; Hans Jürgen Hoffman; Jens M Hohlfeld; Steven M Houser; Peter H Hwang; Cristoforo Incorvaia; Deborah Jarvis; Ayesha N Khalid; Maritta Kilpeläinen; Todd T Kingdom; Helene Krouse; Desiree Larenas-Linnemann; Adrienne M Laury; Stella E Lee; Joshua M Levy; Amber U Luong; Bradley F Marple; Edward D McCoul; K Christopher McMains; Erik Melén; James W Mims; Gianna Moscato; Joaquim Mullol; Harold S Nelson; Monica Patadia; Ruby Pawankar; Oliver Pfaar; Michael P Platt; William Reisacher; Carmen Rondón; Luke Rudmik; Matthew Ryan; Joaquin Sastre; Rodney J Schlosser; Russell A Settipane; Hemant P Sharma; Aziz Sheikh; Timothy L Smith; Pongsakorn Tantilipikorn; Jody R Tversky; Maria C Veling; De Yun Wang; Marit Westman; Magnus Wickman; Mark Zacharek Journal: Int Forum Allergy Rhinol Date: 2018-02 Impact factor: 3.858
Authors: Korneliusz Golebski; Silvia Luiten; Danielle van Egmond; Esther de Groot; Kristina Irene Lisolette Röschmann; Wytske Johanna Fokkens; Cornelis Maria van Drunen Journal: PLoS One Date: 2014-02-03 Impact factor: 3.240