| Literature DB >> 21149677 |
Herbert S Wilf1, Warren J Ewens.
Abstract
Objections to Darwinian evolution are often based on the time required to carry out the necessary mutations. Seemingly, exponential numbers of mutations are needed. We show that such estimates ignore the effects of natural selection, and that the numbers of necessary mutations are thereby reduced to about K log L, rather than K(L), where L is the length of the genomic "word," and K is the number of possible "letters" that can occupy any position in the word. The required theory makes contact with the theory of radix-exchange sorting in theoretical computer science, and the asymptotic analysis of certain sums that occur there.Mesh:
Year: 2010 PMID: 21149677 PMCID: PMC3012492 DOI: 10.1073/pnas.1016207107
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN: 0027-8424 Impact factor: 11.205