UNLABELLED: Radioembolization with 90Y microspheres represents a novel transarterial radiation treatment for liver tumors. The purpose of this pilot study was to evaluate the findings of postimplantation PET/CT of 90Y glass microspheres. METHODS: Three patients with hepatocellular carcinoma and 2 patients with liver metastases (1 neuroendocrine, 1 colorectal) underwent PET/CT after radioembolization. Four patients underwent imaging at 1 mo to assess response and confirm PET/CT findings; 1 patient underwent PET/CT at 4 d after 90Y implantation. Patients were followed for adverse events. RESULTS: Standard PET/CT enabled the localization of 90Y glass microspheres for all patients. None of the patients experienced adverse events related to nontarget deposition. CONCLUSION: Standard PET/CT may be used to assess the localization of 90Y glass microspheres. This approach provides a simple, rapid, and universally applicable method of confirming microsphere deposition. With further validation, this technique may potentially become the standard of care for confirming microsphere distribution.
UNLABELLED: Radioembolization with 90Y microspheres represents a novel transarterial radiation treatment for liver tumors. The purpose of this pilot study was to evaluate the findings of postimplantation PET/CT of 90Y glass microspheres. METHODS: Three patients with hepatocellular carcinoma and 2 patients with liver metastases (1 neuroendocrine, 1 colorectal) underwent PET/CT after radioembolization. Four patients underwent imaging at 1 mo to assess response and confirm PET/CT findings; 1 patient underwent PET/CT at 4 d after 90Y implantation. Patients were followed for adverse events. RESULTS: Standard PET/CT enabled the localization of 90Y glass microspheres for all patients. None of the patients experienced adverse events related to nontarget deposition. CONCLUSION: Standard PET/CT may be used to assess the localization of 90Y glass microspheres. This approach provides a simple, rapid, and universally applicable method of confirming microsphere deposition. With further validation, this technique may potentially become the standard of care for confirming microsphere distribution.
Authors: Weiguo Li; Zhuoli Zhang; Andrew C Gordon; Jeane Chen; Jodi Nicolai; Robert J Lewandowski; Reed A Omary; Andrew C Larson Journal: Radiology Date: 2015-08-27 Impact factor: 11.105
Authors: Stephan Walrand; Glenn D Flux; Mark W Konijnenberg; Roelf Valkema; Eric P Krenning; Renaud Lhommel; Stanislas Pauwels; Francois Jamar Journal: Eur J Nucl Med Mol Imaging Date: 2011-03-11 Impact factor: 9.236
Authors: Michael Wissmeyer; Susanne Heinzer; Pietro Majno; Franz Buchegger; Habib Zaidi; Valentina Garibotto; Magalie Viallon; Christoph D Becker; Osman Ratib; Sylvain Terraz Journal: Eur J Nucl Med Mol Imaging Date: 2011-04-06 Impact factor: 9.236