UNLABELLED: We investigated whether PET/CT angiography using 11C-(R)-PK11195, a selective ligand for the translocator protein (18 kDa) expressed in activated macrophages, could allow imaging and quantification of arterial wall inflammation in patients with large-vessel vasculitis. METHODS: Seven patients with systemic inflammatory disorders (3 symptomatic patients with clinical suspicion of active vasculitis and 4 asymptomatic patients) underwent PET with 11C-(R)-PK11195 and CT angiography to colocalize arterial wall uptake of 11C-(R)-PK11195. Tissue regions of interest were defined in bone marrow, lung parenchyma, wall of the ascending aorta, aortic arch, and descending aorta. Blood-derived and image-derived input functions (IFs) were generated. A reversible 1-tissue compartment with 2 kinetic rate constants and a fractional blood volume term were used to fit the time-activity curves to calculate total volume of distribution (VT). The correlation between VT and standardized uptake values was assessed. RESULTS: VT was significantly higher in symptomatic than in asymptomatic patients using both image-derived total plasma IF (0.55±0.15 vs. 0.27±0.12, P=0.009) and image-derived parent plasma IF (1.40±0.50 vs. 0.58±0.25, P=0.018). A good correlation was observed between VT and standardized uptake value (R=0.79; P=0.03). CONCLUSION: 11C-(R)-PK11195 imaging allows visualization of macrophage infiltration in inflamed arterial walls. Tracer uptake can be quantified with image-derived IF without the need for metabolite corrections and evaluated semiquantitatively with standardized uptake values.
UNLABELLED: We investigated whether PET/CT angiography using 11C-(R)-PK11195, a selective ligand for the translocator protein (18 kDa) expressed in activated macrophages, could allow imaging and quantification of arterial wall inflammation in patients with large-vessel vasculitis. METHODS: Seven patients with systemic inflammatory disorders (3 symptomatic patients with clinical suspicion of active vasculitis and 4 asymptomatic patients) underwent PET with 11C-(R)-PK11195 and CT angiography to colocalize arterial wall uptake of 11C-(R)-PK11195. Tissue regions of interest were defined in bone marrow, lung parenchyma, wall of the ascending aorta, aortic arch, and descending aorta. Blood-derived and image-derived input functions (IFs) were generated. A reversible 1-tissue compartment with 2 kinetic rate constants and a fractional blood volume term were used to fit the time-activity curves to calculate total volume of distribution (VT). The correlation between VT and standardized uptake values was assessed. RESULTS:VT was significantly higher in symptomatic than in asymptomatic patients using both image-derived total plasma IF (0.55±0.15 vs. 0.27±0.12, P=0.009) and image-derived parent plasma IF (1.40±0.50 vs. 0.58±0.25, P=0.018). A good correlation was observed between VT and standardized uptake value (R=0.79; P=0.03). CONCLUSION:11C-(R)-PK11195 imaging allows visualization of macrophage infiltration in inflamed arterial walls. Tracer uptake can be quantified with image-derived IF without the need for metabolite corrections and evaluated semiquantitatively with standardized uptake values.
Authors: DeLisa Fairweather; Michael J Coronado; Amanda E Garton; Jennifer L Dziedzic; Adriana Bucek; Leslie T Cooper; Jessica E Brandt; Fatima S Alikhan; Haofan Wang; Christopher J Endres; Judy Choi; Martin G Pomper; Tomás R Guilarte Journal: J Cardiovasc Transl Res Date: 2014-01-09 Impact factor: 4.132
Authors: Sanna Hellberg; Johanna M U Silvola; Max Kiugel; Heidi Liljenbäck; Nina Savisto; Xiang-Guo Li; Andrea Thiele; Lutz Lehmann; Tobias Heinrich; Sonja Vollmer; Harri Hakovirta; V Jukka O Laine; Seppo Ylä-Herttuala; Juhani Knuuti; Anne Roivainen; Antti Saraste Journal: J Nucl Cardiol Date: 2016-05-25 Impact factor: 5.952
Authors: Delphine L Chen; Eugene Agapov; Kangyun Wu; Jacquelyn T Engle; Kiran Kumar Solingapuram Sai; Elizabeth Arentson; Katherine J Spayd; Kirby T Moreland; Kelsey Toth; Derek E Byers; Richard A Pierce; Jeffrey J Atkinson; Richard Laforest; Andrew E Gelman; Michael J Holtzman Journal: Mol Imaging Biol Date: 2021-06-16 Impact factor: 3.488
Authors: Myra S Cocker; Brian Mc Ardle; J David Spence; Cheemun Lum; Robert R Hammond; Deidre C Ongaro; Matthew A McDonald; Robert A Dekemp; Jean-Claude Tardif; Rob S B Beanlands Journal: J Nucl Cardiol Date: 2012-12 Impact factor: 5.952