Literature DB >> 21148450

Acquired toxoplasmosis accompanied by facial nerve palsy in an immunocompetent 5-year-old child.

Assimina Galli-Tsinopoulou1, Ioannis Kyrgios, Eleni Z Giannopoulou, Styliani Gourgoulia, Ioanna Maggana, Elina Katechaki, Dimitrios Chatzidimitriou, Athanasios E Evangeliou.   

Abstract

Acquired toxoplasmosis, although relatively common in children, is usually asymptomatic but can also be clinically manifested by a benign and self-limited infectious mononucleosis-like syndrome. Neurological complications are very rare in immunocompetent children. The authors report a 5-year-old boy who presented with cervical lymphadenopathy because of acquired toxoplasmosis accompanied with unilateral facial nerve paralysis. Toxoplasma gondii DNA detection in blood by polymerase chain reaction, as well as elevated specific immunoglobulin M antibodies against it, established the diagnosis. Characteristic brain lesions on magnetic resonance imaging were absent and ophthalmologic examination revealed no inflammatory lesions in the retina and choroid. Treatment with pyrimethamine, sulfadiazine, and folic acid resulted in a complete recovery after 2 months of therapy. Although rare, acute facial nerve paralysis of unknown origin can be caused by acquired toxoplasmosis even in the immunocompetent pediatric population. Elevated titers of specific antibodies and the presence of parasite's DNA are key findings for the correct diagnosis.

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Year:  2010        PMID: 21148450     DOI: 10.1177/0883073810370480

Source DB:  PubMed          Journal:  J Child Neurol        ISSN: 0883-0738            Impact factor:   1.987


  2 in total

1.  Cerebral toxoplasmosis diagnosed by brain tissue PCR analysis in an immunocompetent patient.

Authors:  Giuseppe Pustorino; Edoardo Ferlazzo; Maria Stella Carpentieri; Vittoria Cianci; Sara Gasparini; Mauro Campello; Giovanni Luigi Milardi; Antonio Gangemi; Umberto Aguglia
Journal:  Neurol Clin Pract       Date:  2017-10

2.  Recurrent seizures during acute acquired toxoplasmosis in an immunocompetent traveller returning from Africa.

Authors:  Anna Beltrame; Sergio Venturini; Giovanni Crichiutti; Valeria Meroni; Dora Buonfrate; Matteo Bassetti
Journal:  Infection       Date:  2015-07-14       Impact factor: 3.553

  2 in total

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