| Literature DB >> 21147111 |
J C R Cardoso1, R Laiz-Carrion, B Louro, N Silva, A V M Canario, J M Mancera, D M Power.
Abstract
Proopiomelanocorticotrophin (POMC) in vertebrates is produced in the pituitary gland and undergoes post-translational processing to give rise to a range of biologically active peptides. Teleosts possess 2-3 different POMC transcripts which have been proposed to have originated from a whole or partial genome duplication. In the present study 2 transcripts of gilthead sea bream POMC (sbPOMC-α1 and α2) were cloned and characterised. sbPOMC-α1 is expressed principally in the melanotroph cells of the pars intermedia (PI) and sbPOMC-α2 is expressed in the corticotroph cells of the rostral pars distalis and probably also in the PI. The 2 sbPOMC transcripts have a differential tissue distribution in extra-pituitary sites. An appraisal of POMC evolution indicates sbPOMCs belong to one of the two main clades that exist in teleosts and that overall a non conservative process of gene loss occurred in this infraclass.Entities:
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Year: 2010 PMID： 21147111 DOI： 10.1016/j.ygcen.2010.12.001
Source DB: PubMed Journal: Gen Comp Endocrinol ISSN： 0016-6480 Impact factor: 2.822