Literature DB >> 21146531

Dissecting DNA hypermethylation in cancer.

Marcos R H Estécio1, Jean-Pierre J Issa.   

Abstract

There is compelling evidence to support the importance of DNA methylation alterations in cancer development. Both losses and gains of DNA methylation are observed, thought to contribute pathophysiologically by inactivating tumor suppressor genes, inducing chromosomal instability and ectopically activating gene expression. Lesser known are the causes of aberrant DNA methylation. Recent studies have pointed out that intrinsic gene susceptibility to DNA methylation, environmental factors and gene function all have an intertwined participation in this process. Overall, these data support a deterministic rather than a stochastic mechanism for de novo DNA methylation in cancer. In this review article, we discuss the technologies available to study DNA methylation and the endogenous and exogenous factors that influence the onset of de novo methylation in cancer.
Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Year:  2010        PMID： 21146531      PMCID： PMC3378045          DOI： 10.1016/j.febslet.2010.12.001

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  135 in total

1.  Genome architecture marked by retrotransposons modulates predisposition to DNA methylation in cancer.

Authors:  Marcos R H Estécio; Juan Gallegos; Céline Vallot; Ryan J Castoro; Woonbok Chung; Shinji Maegawa; Yasuhiro Oki; Yutaka Kondo; Jaroslav Jelinek; Lanlan Shen; Helge Hartung; Peter D Aplan; Bogdan A Czerniak; Shoudan Liang; Jean-Pierre J Issa
Journal:  Genome Res       Date:  2010-08-17       Impact factor: 9.043

2.  Distinctive signatures of histone methylation in transcribed coding and noncoding human beta-globin sequences.

Authors:  AeRi Kim; Christine M Kiefer; Ann Dean
Journal:  Mol Cell Biol       Date:  2006-12-11       Impact factor: 4.272

3.  Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line.

Authors:  Einav Nili Gal-Yam; Gerda Egger; Leo Iniguez; Heather Holster; Steingrímur Einarsson; Xinmin Zhang; Joy C Lin; Gangning Liang; Peter A Jones; Amos Tanay
Journal:  Proc Natl Acad Sci U S A       Date:  2008-08-27       Impact factor: 11.205

4.  Genome-wide analysis of aberrant methylation in human breast cancer cells using methyl-DNA immunoprecipitation combined with high-throughput sequencing.

Authors:  Yoshinao Ruike; Yukako Imanaka; Fumiaki Sato; Kazuharu Shimizu; Gozoh Tsujimoto
Journal:  BMC Genomics       Date:  2010-02-25       Impact factor: 3.969

5.  Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a.

Authors:  B H Ramsahoye; D Biniszkiewicz; F Lyko; V Clark; A P Bird; R Jaenisch
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-09       Impact factor: 11.205

6.  Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis.

Authors:  Yasuhiro Yamada; Laurie Jackson-Grusby; Heinz Linhart; Alex Meissner; Amir Eden; Haijiang Lin; Rudolf Jaenisch
Journal:  Proc Natl Acad Sci U S A       Date:  2005-09-08       Impact factor: 11.205

7.  Gene-specific and global methylation patterns predict outcome in patients with acute myeloid leukemia.

Authors:  S Deneberg; M Grövdal; M Karimi; M Jansson; H Nahi; A Corbacioglu; V Gaidzik; K Döhner; C Paul; T J Ekström; E Hellström-Lindberg; S Lehmann
Journal:  Leukemia       Date:  2010-03-18       Impact factor: 11.528

8.  DNMT3A mutations in acute myeloid leukemia.

Authors:  Timothy J Ley; Li Ding; Matthew J Walter; Michael D McLellan; Tamara Lamprecht; David E Larson; Cyriac Kandoth; Jacqueline E Payton; Jack Baty; John Welch; Christopher C Harris; Cheryl F Lichti; R Reid Townsend; Robert S Fulton; David J Dooling; Daniel C Koboldt; Heather Schmidt; Qunyuan Zhang; John R Osborne; Ling Lin; Michelle O'Laughlin; Joshua F McMichael; Kim D Delehaunty; Sean D McGrath; Lucinda A Fulton; Vincent J Magrini; Tammi L Vickery; Jasreet Hundal; Lisa L Cook; Joshua J Conyers; Gary W Swift; Jerry P Reed; Patricia A Alldredge; Todd Wylie; Jason Walker; Joelle Kalicki; Mark A Watson; Sharon Heath; William D Shannon; Nobish Varghese; Rakesh Nagarajan; Peter Westervelt; Michael H Tomasson; Daniel C Link; Timothy A Graubert; John F DiPersio; Elaine R Mardis; Richard K Wilson
Journal:  N Engl J Med       Date:  2010-11-10       Impact factor: 91.245

Review 9.  CpG island methylator phenotype in cancer.

Authors:  Jean-Pierre Issa
Journal:  Nat Rev Cancer       Date:  2004-12       Impact factor: 60.716

10.  Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells.

Authors:  Madeleine P Ball; Jin Billy Li; Yuan Gao; Je-Hyuk Lee; Emily M LeProust; In-Hyun Park; Bin Xie; George Q Daley; George M Church
Journal:  Nat Biotechnol       Date:  2009-03-29       Impact factor: 54.908
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  31 in total

Review 1.  DNA methylation regulated gene expression in organ fibrosis.

Authors:  Xiangyu Zhang; Min Hu; Xing Lyu; Chun Li; Victor J Thannickal; Yan Y Sanders
Journal:  Biochim Biophys Acta Mol Basis Dis       Date:  2017-05-10       Impact factor: 5.187

Review 2.  Developmental origins and oncogenic pathways in malignant brain tumors.

Authors:  Q Richard Lu; Lily Qian; Xianyao Zhou
Journal:  Wiley Interdiscip Rev Dev Biol       Date:  2019-04-03       Impact factor: 5.814

3.  Safety and clinical activity of 5-aza-2'-deoxycytidine (decitabine) with or without Hyper-CVAD in relapsed/refractory acute lymphocytic leukaemia.

Authors:  Christopher B Benton; Deborah A Thomas; Hui Yang; Farhad Ravandi; Michael Rytting; Susan O'Brien; Anna R Franklin; Gautam Borthakur; Samuel Dara; Monica Kwari; Sherry R Pierce; Elias Jabbour; Hagop Kantarjian; Guillermo Garcia-Manero
Journal:  Br J Haematol       Date:  2014-07-26       Impact factor: 6.998

4.  Loss of the polycomb mark from bivalent promoters leads to activation of cancer-promoting genes in colorectal tumors.

Authors:  Maria A Hahn; Arthur X Li; Xiwei Wu; Richard Yang; David A Drew; Daniel W Rosenberg; Gerd P Pfeifer
Journal:  Cancer Res       Date:  2014-05-01       Impact factor: 12.701

5.  DNA methylation patterns in bladder tumors of African American patients point to distinct alterations in xenobiotic metabolism.

Authors:  Venkatrao Vantaku; Chandra Sekhar Amara; Danthasinghe Waduge Badrajee Piyarathna; Sri Ramya Donepudi; Chandrashekar R Ambati; Vasanta Putluri; Wei Tang; Kimal Rajapakshe; Marcos Roberto Estecio; Martha K Terris; Patricia D Castro; Michael M Ittmann; Stephen B Williams; Seth P Lerner; Arun Sreekumar; Roni Bollag; Cristian Coarfa; Michael D Kornberg; Yair Lotan; Stefan Ambs; Nagireddy Putluri
Journal:  Carcinogenesis       Date:  2019-11-25       Impact factor: 4.944

6.  Lrig1 is an estrogen-regulated growth suppressor and correlates with longer relapse-free survival in ERα-positive breast cancer.

Authors:  Sheryl R Krig; Seth Frietze; Catalina Simion; Jamie K Miller; Will H D Fry; Hanine Rafidi; Lakmal Kotelawala; Lihong Qi; Obi L Griffith; Joe W Gray; Kermit L Carraway; Colleen Sweeney
Journal:  Mol Cancer Res       Date:  2011-08-05       Impact factor: 5.852

Review 7.  The mechanistic role of DNA methylation in myeloid leukemogenesis.

Authors:  J Jasielec; V Saloura; L A Godley
Journal:  Leukemia       Date:  2014-05-20       Impact factor: 11.528

8.  Analysis of bladder cancer tumor CpG methylation and gene expression within The Cancer Genome Atlas identifies GRIA1 as a prognostic biomarker for basal-like bladder cancer.

Authors:  Sloane K Tilley; William Y Kim; Rebecca C Fry
Journal:  Am J Cancer Res       Date:  2017-09-01       Impact factor: 6.166

9.  Hiwi mediated tumorigenesis is associated with DNA hypermethylation.

Authors:  Sara Siddiqi; Melissa Terry; Igor Matushansky
Journal:  PLoS One       Date:  2012-03-16       Impact factor: 3.240

10.  Sensitive and selective amplification of methylated DNA sequences using helper-dependent chain reaction in combination with a methylation-dependent restriction enzymes.

Authors:  Keith N Rand; Graeme P Young; Thu Ho; Peter L Molloy
Journal:  Nucleic Acids Res       Date:  2012-09-10       Impact factor: 16.971
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