OBJECTIVE: To report a live birth after orthotopic transplantation of cryopreserved ovarian tissue. DESIGN: Case report. SETTING: Department of Gynecology, Cliniques Universitaires Saint-Luc, Brussels. PATIENT(S): Woman with metastatic cancer who had her ovarian tissue cryopreserved in 2001 before undergoing chemotherapy and hematopoietic stem cell transplantation, resulting in premature ovarian failure. INTERVENTION(S): Orthotopic reimplantation of ovarian cortex performed 7 years after cryopreservation. MAIN OUTCOME MEASURE(S): Restoration of ovarian activity. RESULT(S): Restoration of ovarian activity was observed 3.5 months after reimplantantation, and ongoing pregnancy was diagnosed 9 months after grafting. The patient delivered a healthy baby weighing 2.830 kg. CONCLUSION(S): Our patient represents the thirteenth live birth to occur after orthotopic reimplantation of cryopreserved tissue, but the first in a woman treated for metastatic disease.
OBJECTIVE: To report a live birth after orthotopic transplantation of cryopreserved ovarian tissue. DESIGN: Case report. SETTING: Department of Gynecology, Cliniques Universitaires Saint-Luc, Brussels. PATIENT(S): Woman with metastatic cancer who had her ovarian tissue cryopreserved in 2001 before undergoing chemotherapy and hematopoietic stem cell transplantation, resulting in premature ovarian failure. INTERVENTION(S): Orthotopic reimplantation of ovarian cortex performed 7 years after cryopreservation. MAIN OUTCOME MEASURE(S): Restoration of ovarian activity. RESULT(S): Restoration of ovarian activity was observed 3.5 months after reimplantantation, and ongoing pregnancy was diagnosed 9 months after grafting. The patient delivered a healthy baby weighing 2.830 kg. CONCLUSION(S): Our patient represents the thirteenth live birth to occur after orthotopic reimplantation of cryopreserved tissue, but the first in a woman treated for metastatic disease.
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