OBJECTIVE: The purpose of this study was to evaluate whether the use of oxytocin during the first and second stages of labor is associated with a higher incidence of postpartum hemorrhage (PPH) in pregnant women who received active management of third stage of labor (AMTSL). STUDY DESIGN: A secondary data analysis from vaginal deliveries in a hospital-based cohort study from 24 maternity hospitals in South America. The primary outcomes that were analyzed were moderate PPH (≥500 mL of blood loss), severe PPH (≥1000 mL of blood loss), and need of blood transfusion. RESULTS: A total of 11,323 vaginal deliveries were included. The incidence of moderate and severe PPH was 10.8% and 1.86%, respectively. Overall, 36% of deliveries received AMTSL. There was no association between induced/augmented labor and moderate PPH (P = .753), severe PPH (P = .273), and blood transfusion (P = .603) in the population that received AMTSL. CONCLUSION: AMTSL should be recommended, regardless of whether pregnant women received oxytocin during the first and second stages of labor.
RCT Entities:
OBJECTIVE: The purpose of this study was to evaluate whether the use of oxytocin during the first and second stages of labor is associated with a higher incidence of postpartum hemorrhage (PPH) in pregnant women who received active management of third stage of labor (AMTSL). STUDY DESIGN: A secondary data analysis from vaginal deliveries in a hospital-based cohort study from 24 maternity hospitals in South America. The primary outcomes that were analyzed were moderate PPH (≥500 mL of blood loss), severe PPH (≥1000 mL of blood loss), and need of blood transfusion. RESULTS: A total of 11,323 vaginal deliveries were included. The incidence of moderate and severe PPH was 10.8% and 1.86%, respectively. Overall, 36% of deliveries received AMTSL. There was no association between induced/augmented labor and moderate PPH (P = .753), severe PPH (P = .273), and blood transfusion (P = .603) in the population that received AMTSL. CONCLUSION:AMTSL should be recommended, regardless of whether pregnant women received oxytocin during the first and second stages of labor.
Authors: Fernando Althabe; Pierre Buekens; Eduardo Bergel; José M Belizán; Marci K Campbell; Nancy Moss; Tyler Hartwell; Linda L Wright Journal: N Engl J Med Date: 2008-05-01 Impact factor: 91.245
Authors: Fernando Althabe; Pierre Buekens; Eduardo Bergel; José M Belizán; Nora Kropp; Linda Wright; Norman Goco; Nancy Moss Journal: BMC Womens Health Date: 2005-04-11 Impact factor: 2.809
Authors: Elizabeth M McClure; Doris J Rouse; Emily R Macguire; Bonnie Jones; Jennifer B Griffin; Alan H Jobe; Beena D Kamath-Rayne; Craig Shaffer; Robert L Goldenberg Journal: Int J Gynaecol Obstet Date: 2013-01-11 Impact factor: 3.561