PURPOSE: To evaluate the effect of levodopa on apparent diffusion coefficient (ADC) value of the brain parenchyma in patients with idiopathic Parkinson disease (PD). MATERIAL AND METHODS: Prospective study was conducted on native PD without treatment (n = 25) and patients receiving levodopa (L-Dopa) (n = 25). Diffusion magnetic resonance-weighted imaging was done using a single-shot spin echo type of echo planar imaging. The apparent diffusion coefficient (ADC) value at different regions of the brain on both sides was calculated. RESULTS: The ADC value of the putamen in patients with native PD was 0.732 ± 0.15 × 10-3 mm2/seconds and in patients receiving levodopa was 0.789 ± 0.24 × 10-3 mm2/second. There was a statistically significant difference in the ADC value at the putamen (P = .001) between patients with native PD and patients receiving levodopa. When ADC value of the putamen at 0.745 × 10-3 mm2/second was used as a threshold value for differentiating native PD patients and patients receiving L-Dopa, the best results were obtained with an accuracy of 82%, sensitivity of 92%, specificity of 72%, positive predictive value of 77%, negative predictive value of 90%, and area under the curve of 0.955. CONCLUSION: ADC value of the putamen is a promising parameter for predication of effect of levodopa on brain parenchyma in patients with PD.
PURPOSE: To evaluate the effect of levodopa on apparent diffusion coefficient (ADC) value of the brain parenchyma in patients with idiopathic Parkinson disease (PD). MATERIAL AND METHODS: Prospective study was conducted on native PD without treatment (n = 25) and patients receiving levodopa (L-Dopa) (n = 25). Diffusion magnetic resonance-weighted imaging was done using a single-shot spin echo type of echo planar imaging. The apparent diffusion coefficient (ADC) value at different regions of the brain on both sides was calculated. RESULTS: The ADC value of the putamen in patients with native PD was 0.732 ± 0.15 × 10-3 mm2/seconds and in patients receiving levodopa was 0.789 ± 0.24 × 10-3 mm2/second. There was a statistically significant difference in the ADC value at the putamen (P = .001) between patients with native PD and patients receiving levodopa. When ADC value of the putamen at 0.745 × 10-3 mm2/second was used as a threshold value for differentiating native PDpatients and patients receiving L-Dopa, the best results were obtained with an accuracy of 82%, sensitivity of 92%, specificity of 72%, positive predictive value of 77%, negative predictive value of 90%, and area under the curve of 0.955. CONCLUSION: ADC value of the putamen is a promising parameter for predication of effect of levodopa on brain parenchyma in patients with PD.
Authors: Frederick J A Meijer; Anouke van Rumund; Anil M Tuladhar; Marjolein B Aerts; Imke Titulaer; Rianne A J Esselink; Bastiaan R Bloem; Marcel M Verbeek; Bozena Goraj Journal: Neuroradiology Date: 2015-04-07 Impact factor: 2.804
Authors: Regina Esterhammer; Klaus Seppi; Eva Reiter; Bernadette Pinter; Christoph Mueller; Christian Kremser; Tanja Zitzelsberger; Michael Nocker; Christoph Scherfler; Werner Poewe; Michael Schocke Journal: PLoS One Date: 2015-12-29 Impact factor: 3.240
Authors: H Takeuchi; Y Taki; H Hashizume; K Asano; M Asano; Y Sassa; S Yokota; Y Kotozaki; R Nouchi; R Kawashima Journal: Mol Psychiatry Date: 2016-01-05 Impact factor: 15.992