BACKGROUND: Human formyl peptide receptor 1 (FPR1) mediates inflammatory responses, recognized as important participants in the physiopathology of hypertension. Similarly, FPR1 C32T SNP is associated with inflammation and BP related pathways. Therefore, the relationship between FPR1 C32T SNP, BP and hypertension needs to be investigated. METHOD: 1012 French middle-aged adults including 491 healthy individuals (5 years follow-up, T(+0) and T(+5)) and 521 hypertensive individuals were PCR-RFLP genotyped for FPR1 C32T SNP (rs5030878). RESULTS: At entrance, there was no significant association between FPR1 C32T SNP and blood pressure (BP) in healthy individuals. However, 5 years later, significant associations were found for DBP, SBP (p<0.001 and p=0.009 respectively) and for their 5 years changes (Δ) (p=0.025 and p=0.027 for DBP and SBP respectively). Significant interactions between FPR1 C32T SNP and age on DBP, SBP, ΔDBP and ΔSBP were found (p=0.014, 0.008, 0.015 and 0.015 respectively). Consequently, stronger increase in BP was reported among healthy individuals aged less than 45 years. When normotensive individuals were compared to hypertensives ones, similar FPR1 C32T genotypes and allele frequency distributions were found. CONCLUSION: FPR1 C32T SNP interacts with age, is associated with higher and a 5 years increase of BP levels in healthy individuals aged less than 45 years.
BACKGROUND:Humanformyl peptide receptor 1 (FPR1) mediates inflammatory responses, recognized as important participants in the physiopathology of hypertension. Similarly, FPR1 C32T SNP is associated with inflammation and BP related pathways. Therefore, the relationship between FPR1 C32T SNP, BP and hypertension needs to be investigated. METHOD: 1012 French middle-aged adults including 491 healthy individuals (5 years follow-up, T(+0) and T(+5)) and 521 hypertensive individuals were PCR-RFLP genotyped for FPR1 C32T SNP (rs5030878). RESULTS: At entrance, there was no significant association between FPR1 C32T SNP and blood pressure (BP) in healthy individuals. However, 5 years later, significant associations were found for DBP, SBP (p<0.001 and p=0.009 respectively) and for their 5 years changes (Δ) (p=0.025 and p=0.027 for DBP and SBP respectively). Significant interactions between FPR1 C32T SNP and age on DBP, SBP, ΔDBP and ΔSBP were found (p=0.014, 0.008, 0.015 and 0.015 respectively). Consequently, stronger increase in BP was reported among healthy individuals aged less than 45 years. When normotensive individuals were compared to hypertensives ones, similar FPR1 C32T genotypes and allele frequency distributions were found. CONCLUSION:FPR1 C32T SNP interacts with age, is associated with higher and a 5 years increase of BP levels in healthy individuals aged less than 45 years.
Authors: David A Dorward; Christopher D Lucas; Gavin B Chapman; Christopher Haslett; Kevin Dhaliwal; Adriano G Rossi Journal: Am J Pathol Date: 2015-03-17 Impact factor: 4.307
Authors: Said El Shamieh; Ndeye Coumba Ndiaye; Maria G Stathopoulou; Helena A Murray; Christine Masson; John V Lamont; Peter Fitzgerald; Athanase Benetos; Sophie Visvikis-Siest Journal: PLoS One Date: 2012-07-18 Impact factor: 3.240
Authors: Caihong Zhou; Yan Zhou; Jia Wang; Yang Feng; Haonan Wang; Jinglun Xue; Yani Chen; Richard D Ye; Ming-Wei Wang Journal: Biochem J Date: 2013-04-15 Impact factor: 3.857