| Literature DB >> 21144623 |
Geng Xu1, Zheng Yan, Nan Wang, Zhanzhu Liu.
Abstract
A series of novel cisplatin-type platinum complexes with (1S,3S)-1,2,3,4-tetrahydroisoquinolines as the ligands were synthesized as potential anticancer agents in several steps starting from commercially available l-DOPA. The cytotoxicities of these compounds were tested against HCT-8, BEL-7402, A2780, MCF-7, Hela, A549 and BGC-823 cell lines by the MTT test. Some compounds exhibited better cytotoxic activity than cisplatin. The structure-activity relationship has been revealed.Entities:
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Year: 2010 PMID： 21144623 DOI： 10.1016/j.ejmech.2010.11.025
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514