Literature DB >> 2114420

Antibacterial polysaccharide antibody deficiency after allogeneic bone marrow transplantation.

I Quinti1, A Velardi, S Le Moli, E Guerra, R D'Amelio, P Mastrantonio, M F Martelli, F Aiuti.   

Abstract

Allogeneic bone marrow-engrafted adults immunized with meningococcal types A and C and pneumococcal type 14 polysaccharide antigens showed only low antibody titers of the IgM class, no antibody titers of the IgG or IgA classes, and no bactericidal activity in vitro. The analytical isoelectrofocusing showed the appearance of a restricted pattern of clonotypes in a minority of subjects. These observations are consistent with the hypothesis that B cells in bone marrow transplant patients express some characteristics of neonatal B cells and suggest that polysaccharide-protein conjugates, rather than isolated polysaccharide, might be utilized in the setting of bone marrow transplantation.

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Year:  1990        PMID： 2114420     DOI： 10.1007/bf00917916

Source DB:  PubMed          Journal:  J Clin Immunol        ISSN： 0271-9142            Impact factor:   8.317


  26 in total

1.  New Classification of Neisseria meningitidis by Means of Bactericidal Reactions.

Authors:  R Gold; F A Wyle
Journal:  Infect Immun       Date:  1970-05       Impact factor: 3.441

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Authors:  M Hokland; N Jacobsen; J Ellegaard; P Hokland
Journal:  Transplantation       Date:  1988-06       Impact factor: 4.939

3.  Immunoglobulins in ataxia-telangiectasia: evidence for IgG4 and IgA2 subclass deficiencies.

Authors:  L Rivat-Peran; D Buriot; J P Salier; C Rivat; S M Dumitresco; C Griscelli
Journal:  Clin Immunol Immunopathol       Date:  1981-07

4.  Correlation between serum IgG-2 concentrations and the antibody response to bacterial polysaccharide antigens.

Authors:  G R Siber; P H Schur; A C Aisenberg; S A Weitzman; G Schiffman
Journal:  N Engl J Med       Date:  1980-07-24       Impact factor: 91.245

5.  Efficacy of Haemophilus influenzae type b polysaccharide-diphtheria toxoid conjugate vaccine in infancy.

Authors:  J Eskola; H Peltola; A K Takala; H Käyhty; M Hakulinen; V Karanko; E Kela; P Rekola; P R Rönnberg; J S Samuelson
Journal:  N Engl J Med       Date:  1987-09-17       Impact factor: 91.245

6.  Immunization of humans with polyribophosphate, the capsular antigen of Hemophilus influenzae, type b.

Authors:  P Anderson; G Peter; R B Johnston; L H Wetterlow; D H Smith
Journal:  J Clin Invest       Date:  1972-01       Impact factor: 14.808

7.  Lyb-5- B cells of CBA/N mice can be induced to synthesize DNA by culture with insolubilized but not soluble anti-Ig.

Authors:  J J Mond; M Schaefer; J Smith; F D Finkelman
Journal:  J Immunol       Date:  1983-11       Impact factor: 5.422

8.  Recurrent sinopulmonary infection and impaired antibody response to bacterial capsular polysaccharide antigen in children with selective IgG-subclass deficiency.

Authors:  D T Umetsu; D M Ambrosino; I Quinti; G R Siber; R S Geha
Journal:  N Engl J Med       Date:  1985-11-14       Impact factor: 91.245

9.  Recovery of antibody production in human allogeneic marrow graft recipients: influence of time posttransplantation, the presence or absence of chronic graft-versus-host disease, and antithymocyte globulin treatment.

Authors:  R P Witherspoon; R Storb; H D Ochs; N Fluornoy; K J Kopecky; K M Sullivan; J H Deeg; R Sosa; D R Noel; K Atkinson; E D Thomas
Journal:  Blood       Date:  1981-08       Impact factor: 22.113

10.  Natural killer cell regulation of age-related and type-specific variations in antibody responses to pneumococcal polysaccharides.

Authors:  M Khater; J Macai; C Genyea; J Kaplan
Journal:  J Exp Med       Date:  1986-11-01       Impact factor: 14.307
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  4 in total

1.  Immunization with Haemophilus influenzae type b conjugate vaccine in children given bone marrow transplantation: comparison with healthy age-matched controls.

Authors:  M A Avanzini; A M Carrà; R Maccario; M Zecca; G Zecca; A Pession; P Comoli; M Bozzola; A Prete; R Esposito; F Bonetti; F Locatelli
Journal:  J Clin Immunol       Date:  1998-05       Impact factor: 8.317

2.  Pneumococcal immunity and response to immunization with pneumococcal vaccine in bone marrow transplant patients: the influence of graft versus host reaction.

Authors:  V Hammarström; K Pauksen; J Azinge; G Oberg; P Ljungman
Journal:  Support Care Cancer       Date:  1993-07       Impact factor: 3.603

3.  Antibody response to pneumococcal vaccine in children receiving bone marrow transplantation.

Authors:  M A Avanzini; A M Carra; R Maccario; M Zecca; P Pignatti; M Marconi; P Comoli; F Bonetti; P De Stefano; F Locatelli
Journal:  J Clin Immunol       Date:  1995-05       Impact factor: 8.317

4.  Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infections are generated in the spleen.

Authors:  Stephanie Kruetzmann; M Manuela Rosado; Holger Weber; Ulrich Germing; Olivier Tournilhac; Hans-Hartmut Peter; Reinhard Berner; Anke Peters; Thomas Boehm; Alessandro Plebani; Isabella Quinti; Rita Carsetti
Journal:  J Exp Med       Date:  2003-04-07       Impact factor: 14.307
  4 in total

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