Literature DB >> 21143115

Aurora B: a new prognostic marker and therapeutic target in cancer.

G Portella1, C Passaro, P Chieffi.   

Abstract

Aurora B is a serine-threonine kinase belonging to the highly conserved Aurora family of mitotic kinases. Aurora B is a chromosomal passenger protein involved in chromosome segregation, spindle-checkpoint, and cytokinesis. Alteration of each of these steps could induce aneuploidy, one of main features, and driving force of cancer progression. The overexpression of Aurora B has been observed in several tumor types, and has been linked with a poor prognosis of cancer patients. In this review we will focus on the role of Aurora B in cancer development, its role as a prognostic marker, and the clinical outcome of recently developed Aurora(s) inhibitors.
© 2011 Bentham Science Publishers Ltd.

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Year:  2011        PMID： 21143115     DOI： 10.2174/092986711794480203

Source DB:  PubMed          Journal:  Curr Med Chem        ISSN： 0929-8673            Impact factor:   4.530


  40 in total

1.  Development of o-chlorophenyl substituted pyrimidines as exceptionally potent aurora kinase inhibitors.

Authors:  Matthew P Martin; Yunting Luo; Roberta Pireddu; Hua Yang; Harsukh Gevariya; Harshani R Lawrence; Sevil Ozcan; Jin-Yi Zhu; Robert Kendig; Mercedes Rodriguez; Roy Elias; Jin Q Cheng; Saïd M Sebti; Ernst Schonbrunn; Nicholas J Lawrence
Journal:  J Med Chem       Date:  2012-08-30       Impact factor: 7.446

2.  An up-date on epigenetic and molecular markers in testicular germ cell tumors.

Authors:  Paolo Chieffi
Journal:  Intractable Rare Dis Res       Date:  2017-11

Review 3.  Recent advances in the biology of germ cell tumors: implications for the diagnosis and treatment.

Authors:  P Chieffi; S Chieffi; R Franco; A A Sinisi
Journal:  J Endocrinol Invest       Date:  2012-11-12       Impact factor: 4.256

4.  Functional analysis of KIF20A, a potential immunotherapeutic target for glioma.

Authors:  Katsuya Saito; Shigeki Ohta; Yutaka Kawakami; Kazunari Yoshida; Masahiro Toda
Journal:  J Neurooncol       Date:  2017-01-09       Impact factor: 4.130

5.  The Potential Contribution of microRNAs in Anti-cancer Effects of Aurora Kinase Inhibitor (AZD1152-HQPA).

Authors:  Ali Zekri; Yashar Mesbahi; Elham Boustanipour; Zahra Sadr; Seyed H Ghaffari
Journal:  J Mol Neurosci       Date:  2018-07-26       Impact factor: 3.444

6.  A phase 1 study of AMG 900, an orally administered pan-aurora kinase inhibitor, in adult patients with acute myeloid leukemia.

Authors:  Hagop M Kantarjian; Michael W Schuster; Nitin Jain; Anjali Advani; Elias Jabbour; Erick Gamelin; Erik Rasmussen; Gloria Juan; Abraham Anderson; Vincent F Chow; Gregory Friberg; Florian D Vogl; Mikkael A Sekeres
Journal:  Am J Hematol       Date:  2017-06-05       Impact factor: 10.047

Review 7.  Aurora B kinase: a potential drug target for cancer therapy.

Authors:  Azaj Ahmed; Anas Shamsi; Taj Mohammad; Gulam Mustafa Hasan; Asimul Islam; Md Imtaiyaz Hassan
Journal:  J Cancer Res Clin Oncol       Date:  2021-05-28       Impact factor: 4.553

8.  New perspective on molecular markers as promising therapeutic targets in germ cell tumors.

Authors:  Paolo Chieffi
Journal:  Intractable Rare Dis Res       Date:  2016-05

9.  Ceftriaxone, an FDA-approved cephalosporin antibiotic, suppresses lung cancer growth by targeting Aurora B.

Authors:  Xiang Li; Haitao Li; Shengqing Li; Feng Zhu; Dong Joon Kim; Hua Xie; Yan Li; Janos Nadas; Naomi Oi; Tatyana A Zykova; Dong Hoon Yu; Mee-Hyun Lee; Myoung Ok Kim; Lei Wang; Weiya Ma; Ronald A Lubet; Ann M Bode; Ziming Dong; Zigang Dong
Journal:  Carcinogenesis       Date:  2012-09-07       Impact factor: 4.944

10.  Aurora B: A new promising therapeutic target in cancer.

Authors:  Paolo Chieffi
Journal:  Intractable Rare Dis Res       Date:  2018-05
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