INTRODUCTION: Pancreatic cancer presents the worst survival rates of all neoplasms. Surgical resection is the only potentially curative treatment, but is associated with high complication rates and outcome is bad even in those resected cases. Therefore, candidates amenable for resection must be carefully selected. Identification of prognostic factors preoperatively may help to improve the treatment of these patients, focusing on individually management based on the expected response. PATIENTS AND METHODS: We perform a retrospective study of 59 patients with histological diagnosis of pancreatic carcinoma between 1999 and 2003, looking for possible prognostic factors. RESULTS: We analyze 59 patients, 32 males and 27 females with a mean age of 63.8 years. All the patients were operated, performing palliative surgery in 32% and tumoral resection in 68%, including pancreaticoduodenectomies in 51% and distal pancreatectomy in 17%. Median global survival was 14 months (Range 1-110).We observed that preoperative levels of hemoglobin under 12 g/dl (p = 0.0006) and serum albumina under 2.8 g/dl (p = 0.021) are associated with worse survival. CONCLUSION: Preoperative levels of hemoglobin and serum albumina may be prognostic indicators in pancreatic cancer.
INTRODUCTION:Pancreatic cancer presents the worst survival rates of all neoplasms. Surgical resection is the only potentially curative treatment, but is associated with high complication rates and outcome is bad even in those resected cases. Therefore, candidates amenable for resection must be carefully selected. Identification of prognostic factors preoperatively may help to improve the treatment of these patients, focusing on individually management based on the expected response. PATIENTS AND METHODS: We perform a retrospective study of 59 patients with histological diagnosis of pancreatic carcinoma between 1999 and 2003, looking for possible prognostic factors. RESULTS: We analyze 59 patients, 32 males and 27 females with a mean age of 63.8 years. All the patients were operated, performing palliative surgery in 32% and tumoral resection in 68%, including pancreaticoduodenectomies in 51% and distal pancreatectomy in 17%. Median global survival was 14 months (Range 1-110).We observed that preoperative levels of hemoglobin under 12 g/dl (p = 0.0006) and serum albumina under 2.8 g/dl (p = 0.021) are associated with worse survival. CONCLUSION: Preoperative levels of hemoglobin and serum albumina may be prognostic indicators in pancreatic cancer.
Authors: Aino Salmiheimo; Harri Mustonen; Ulf-Håkan Stenman; Pauli Puolakkainen; Esko Kemppainen; Hanna Seppänen; Caj Haglund Journal: PLoS One Date: 2016-09-15 Impact factor: 3.240
Authors: Jun Wan; Shiping Xu; Yinqiao Wu; Benyan Wu; Dezhong Joshua Liao; Ningzhi Xu; Gangshi Wang Journal: Support Care Cancer Date: 2018-02-07 Impact factor: 3.603
Authors: Dominik Andreas Barth; Carina Brenner; Jakob Michael Riedl; Felix Prinz; Eva Valentina Klocker; Konstantin Schlick; Peter Kornprat; Karoline Lackner; Herbert Stöger; Michael Stotz; Armin Gerger; Martin Pichler Journal: Cancer Med Date: 2020-06-14 Impact factor: 4.711