Literature DB >> 21141968

γ-Secretase modulators as potential disease modifying anti-Alzheimer's drugs.

Daniel Oehlrich1, Didier J-C Berthelot, Harrie J M Gijsen.   

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Year:  2010        PMID： 21141968     DOI： 10.1021/jm101168r

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  39 in total

Review 1.  Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and presenilin.

Authors:  Johannes Prox; Andrea Rittger; Paul Saftig
Journal:  Exp Brain Res       Date:  2011-11-27       Impact factor: 1.972

Review 2.  Dynamic Nature of presenilin1/γ-Secretase: Implication for Alzheimer's Disease Pathogenesis.

Authors:  Katarzyna Marta Zoltowska; Oksana Berezovska
Journal:  Mol Neurobiol       Date:  2017-03-22       Impact factor: 5.590

Review 3.  γ-Secretase and its modulators: Twenty years and beyond.

Authors:  Weiming Xia
Journal:  Neurosci Lett       Date:  2019-02-11       Impact factor: 3.046

4.  BMS-708,163 targets presenilin and lacks notch-sparing activity.

Authors:  Christina J Crump; Suita V Castro; Feng Wang; Nikolay Pozdnyakov; T Eric Ballard; Sangram S Sisodia; Kelly R Bales; Douglas S Johnson; Yue-Ming Li
Journal:  Biochemistry       Date:  2012-09-04       Impact factor: 3.162

5.  Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production.

Authors:  Johanna Wanngren; Jan Ottervald; Santiago Parpal; Erik Portelius; Kia Strömberg; Tomas Borgegård; Rebecka Klintenberg; Anders Juréus; Jenny Blomqvist; Kaj Blennow; Henrik Zetterberg; Johan Lundkvist; Susanne Rosqvist; Helena Karlström
Journal:  J Biol Chem       Date:  2012-07-31       Impact factor: 5.157

6.  Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator.

Authors:  Koji Takeo; Shun Tanimura; Takehiro Shinoda; Satoko Osawa; Ivan Krasmirov Zahariev; Naoki Takegami; Yoshiko Ishizuka-Katsura; Naoko Shinya; Shizuka Takagi-Niidome; Aya Tominaga; Noboru Ohsawa; Tomomi Kimura-Someya; Mikako Shirouzu; Satoshi Yokoshima; Shigeyuki Yokoyama; Tohru Fukuyama; Taisuke Tomita; Takeshi Iwatsubo
Journal:  Proc Natl Acad Sci U S A       Date:  2014-07-09       Impact factor: 11.205

7.  Initial Optimization of a New Series of γ-Secretase Modulators Derived from a Triterpene Glycoside.

Authors:  Nathan O Fuller; Jed L Hubbs; Wesley F Austin; Steffen P Creaser; Timothy D McKee; Robyn M B Loureiro; Barbara Tate; Weiming Xia; Jeffrey L Ives; Mark A Findeis; Brian S Bronk
Journal:  ACS Med Chem Lett       Date:  2012-08-29       Impact factor: 4.345

Review 8.  γ-Secretase inhibitors and modulators: Mechanistic insights into the function and regulation of γ-Secretase.

Authors:  Pengju Nie; Abhishek Vartak; Yue-Ming Li
Journal:  Semin Cell Dev Biol       Date:  2020-04-02       Impact factor: 7.727

Review 9.  Development and mechanism of γ-secretase modulators for Alzheimer's disease.

Authors:  Christina J Crump; Douglas S Johnson; Yue-Ming Li
Journal:  Biochemistry       Date:  2013-05-02       Impact factor: 3.162

10.  Steroids as γ-secretase modulators.

Authors:  Joo In Jung; Thomas B Ladd; Thomas Kukar; Ashleigh R Price; Brenda D Moore; Edward H Koo; Todd E Golde; Kevin M Felsenstein
Journal:  FASEB J       Date:  2013-05-28       Impact factor: 5.191
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