Literature DB >> 21140228

Research traditions and evolutionary explanations in medicine.

Pierre-Olivier Méthot1.   

Abstract

In this article, I argue that distinguishing 'evolutionary' from 'Darwinian' medicine will help us assess the variety of roles that evolutionary explanations can play in a number of medical contexts. Because the boundaries of evolutionary and Darwinian medicine overlap to some extent, however, they are best described as distinct 'research traditions' rather than as competing paradigms. But while evolutionary medicine does not stand out as a new scientific field of its own, Darwinian medicine is united by a number of distinctive theoretical and methodological claims. For example, evolutionary medicine and Darwinian medicine can be distinguished with respect to the styles of evolutionary explanations they employ. While the former primarily involves 'forward looking' explanations, the latter depends mostly on 'backward looking' explanations. A forward looking explanation tries to predict the effects of ongoing evolutionary processes on human health and disease in contemporary environments (e.g., hospitals). In contrast, a backward looking explanation typically applies evolutionary principles from the vantage point of humans' distant biological past in order to assess present states of health and disease. Both approaches, however, are concerned with the prevention and control of human diseases. In conclusion, I raise some concerns about the claim that 'nothing in medicine makes sense except in the light of evolution'.

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Year:  2011        PMID: 21140228     DOI: 10.1007/s11017-010-9167-4

Source DB:  PubMed          Journal:  Theor Med Bioeth        ISSN: 1386-7415


  28 in total

Review 1.  Evolution in health and disease: work in progress.

Authors:  S C Stearns; D Ebert
Journal:  Q Rev Biol       Date:  2001-12       Impact factor: 4.875

2.  'Like all that lives': biology, medicine and bacteria in the age of Pasteur and Koch.

Authors:  J Andrew Mendelsohn
Journal:  Hist Philos Life Sci       Date:  2002       Impact factor: 1.205

3.  Ecological theory suggests that antimicrobial cycling will not reduce antimicrobial resistance in hospitals.

Authors:  Carl T Bergstrom; Monique Lo; Marc Lipsitch
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-12       Impact factor: 11.205

Review 4.  Pathophysiology and management of fever.

Authors:  Shalini Dalal; Donna S Zhukovsky
Journal:  J Support Oncol       Date:  2006-01

5.  In what sense does 'nothing make sense except in the light of evolution'?

Authors:  Paul Edmund Griffiths
Journal:  Acta Biotheor       Date:  2008-09-06       Impact factor: 1.774

Review 6.  The dawn of Darwinian medicine.

Authors:  G C Williams; R M Nesse
Journal:  Q Rev Biol       Date:  1991-03       Impact factor: 4.875

7.  The spandrels of San Marco and the Panglossian paradigm: a critique of the adaptationist programme.

Authors:  S J Gould; R C Lewontin
Journal:  Proc R Soc Lond B Biol Sci       Date:  1979-09-21

Review 8.  Changing patterns of infectious disease.

Authors:  M L Cohen
Journal:  Nature       Date:  2000-08-17       Impact factor: 49.962

9.  Outpatient antibiotic use in Europe and association with resistance: a cross-national database study.

Authors:  Herman Goossens; Matus Ferech; Robert Vander Stichele; Monique Elseviers
Journal:  Lancet       Date:  2005 Feb 12-18       Impact factor: 79.321

Review 10.  Evolutionary medicine.

Authors:  B Swynghedauw
Journal:  Acta Chir Belg       Date:  2004-04       Impact factor: 1.090

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  3 in total

1.  Patterns of Infection and Patterns of Evolution: How a Malaria Parasite Brought "Monkeys and Man" Closer Together in the 1960s.

Authors:  Rachel Mason Dentinger
Journal:  J Hist Biol       Date:  2016-04       Impact factor: 1.326

2.  Evolution and medicine in undergraduate education: a prescription for all biology students.

Authors:  Michael F Antolin; Kristin P Jenkins; Carl T Bergstrom; Bernard J Crespi; Subhajyoti De; Angela Hancock; Kathryn A Hanley; Thomas R Meagher; Andres Moreno-Estrada; Randolph M Nesse; Gilbert S Omenn; Stephen C Stearns
Journal:  Evolution       Date:  2012-02-06       Impact factor: 3.694

Review 3.  What is a pathogen? Toward a process view of host-parasite interactions.

Authors:  Pierre-Olivier Méthot; Samuel Alizon
Journal:  Virulence       Date:  2014       Impact factor: 5.882

  3 in total

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