| Literature DB >> 21139355 |
Kazutaka Kanai1, Naoyuki Itoh, Yoshimasa Ito, Noriaki Nagai, Yasutomo Hori, Seishirou Chikazawa, Fumio Hoshi, Seiichi Higuchi.
Abstract
To investigate potency of oral disulfiram (DSF) compared with that of dexamethasone (Dexa), on endotoxin-induced uveitis (EIU) in rats. The oral administration with 750 mg/kg DSF suppressed the number of inflammatory cells, protein concentration, and levels of tumor necrosis factor (TNF)-α, Nitric oxide (NO) and prostaglandin (PG) E2 in the aqueous humor and improved the histiologic status of the ocular tissue at 24 hr after lipopolysaccharide (LPS) injection. The anti-inflammatory potency of DSF oral administration was as strong as that observed with 0.5 mg/kg Dexa in the present study. The results suggest that DSF might pave the way for a novel therapeutic agent for the management of uveitis.Entities:
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Year: 2010 PMID： 21139355 DOI： 10.1292/jvms.10-0239
Source DB: PubMed Journal: J Vet Med Sci ISSN： 0916-7250 Impact factor: 1.267