Literature DB >> 21139345

Silencing of the gene for homeobox protein HOXB13 by siRNA confers resistance to methylmercury on HEK293 cells.

Gi-Wook Hwang1, Katsunori Ryoke, Tsutomu Takahashi, Akira Naganuma.   

Abstract

Methylmercury is an environmental pollutant that causes severe central nervous system disorders. We searched for transcription factors involved in the development of methylmercury toxicity and found that the decreased expression of a homeobox protein, HOXB13, in HEK293 cells conferred strong resistance to methylmercury.

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Year:  2010        PMID: 21139345     DOI: 10.2131/jts.35.941

Source DB:  PubMed          Journal:  J Toxicol Sci        ISSN: 0388-1350            Impact factor:   2.196


  1 in total

1.  The Nuclear Protein HOXB13 Enhances Methylmercury Toxicity by Inducing Oncostatin M and Promoting Its Binding to TNFR3 in Cultured Cells.

Authors:  Takashi Toyama; Sidi Xu; Ryo Nakano; Takashi Hasegawa; Naoki Endo; Tsutomu Takahashi; Jin-Yong Lee; Akira Naganuma; Gi-Wook Hwang
Journal:  Cells       Date:  2019-12-23       Impact factor: 6.600

  1 in total

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