Literature DB >> 21136123

Insulin-resistant brain state (IRBS) changes membrane composition of fatty acids in temporal and entorhinal brain cortices of rats: relevance to sporadic Alzheimer's disease?

Konstanze Plaschke1, Dorothea Müller, Siegfried Hoyer.   

Abstract

An insulin-resistant brain state (IRBS) was induced by intracerebroventricular application of the diabetogenic substance streptozotocin (STZ) to investigate changes in cerebral fatty acids. Six weeks after the first STZ injection, increases were found in the concentrations of palmitic and stearic acid in temporal cortex; and of palmitic acid in entorhinal cortex indicative of membrane phospholipid breakdown, and damage of the membrane structure. The relevance of these changes is discussed in relation to sporadic Alzheimer's disease.

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Year:  2010        PMID： 21136123     DOI： 10.1007/s00702-010-0523-3

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  26 in total

1.  Hippocampal and cognitive aging across the lifespan: a bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment.

Authors:  Inga Kadish; Olivier Thibault; Eric M Blalock; Kuey-C Chen; John C Gant; Nada M Porter; Philip W Landfield
Journal:  J Neurosci       Date:  2009-02-11       Impact factor: 6.167

2.  Alzheimer-like changes in protein kinase B and glycogen synthase kinase-3 in rat frontal cortex and hippocampus after damage to the insulin signalling pathway.

Authors:  Melita Salkovic-Petrisic; Florian Tribl; Manuela Schmidt; Siegfried Hoyer; Peter Riederer
Journal:  J Neurochem       Date:  2006-01-12       Impact factor: 5.372

3.  Action of the diabetogenic drug streptozotocin on glycolytic and glycogenolytic metabolism in adult rat brain cortex and hippocampus.

Authors:  K Plaschke; S Hoyer
Journal:  Int J Dev Neurosci       Date:  1993-08       Impact factor: 2.457

4.  Free-fatty acid inhibition of insulin binding, degradation, and action in isolated rat hepatocytes.

Authors:  J Svedberg; P Björntorp; U Smith; P Lönnroth
Journal:  Diabetes       Date:  1990-05       Impact factor: 9.461

5.  Decreased autophosphorylation of the insulin receptor-kinase in streptozotocin-diabetic rats.

Authors:  T Kadowaki; M Kasuga; Y Akanuma; O Ezaki; F Takaku
Journal:  J Biol Chem       Date:  1984-11-25       Impact factor: 5.157

6.  Degradation of membrane phospholipids in the cultured human astroglial cell line UC-11MG during ATP depletion.

Authors:  F F Sun; W E Fleming; B M Taylor
Journal:  Biochem Pharmacol       Date:  1993-03-09       Impact factor: 5.858

Review 7.  Membrane lipid composition and cellular function.

Authors:  A A Spector; M A Yorek
Journal:  J Lipid Res       Date:  1985-09       Impact factor: 5.922

Review 8.  Phospholipid methylation and biological signal transmission.

Authors:  F Hirata; J Axelrod
Journal:  Science       Date:  1980-09-05       Impact factor: 47.728

9.  Streptozotocin increases free fatty acids and decreases phospholipids in rat brain.

Authors:  D Müller; R M Nitsch; R J Wurtman; S Hoyer
Journal:  J Neural Transm (Vienna)       Date:  1998       Impact factor: 3.575

10.  Reduced membrane lipids in the cortex of Alzheimer's disease transgenic mice.

Authors:  Jeffrey K Yao; Thomas M Wengenack; Geoffry L Curran; Joseph F Poduslo
Journal:  Neurochem Res       Date:  2008-03-29       Impact factor: 3.996
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  5 in total

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Authors:  Olivier Thibault; Katie L Anderson; Chris DeMoll; Lawrence D Brewer; Philip W Landfield; Nada M Porter
Journal:  Eur J Pharmacol       Date:  2013-07-17       Impact factor: 4.432

Review 2.  The diabetic brain and cognition.

Authors:  Peter Riederer; Amos D Korczyn; Sameh S Ali; Ovidiu Bajenaru; Mun Seong Choi; Michael Chopp; Vesna Dermanovic-Dobrota; Edna Grünblatt; Kurt A Jellinger; Mohammad Amjad Kamal; Warda Kamal; Jerzy Leszek; Tanja Maria Sheldrick-Michel; Gohar Mushtaq; Bernard Meglic; Rachel Natovich; Zvezdan Pirtosek; Martin Rakusa; Melita Salkovic-Petrisic; Reinhold Schmidt; Angelika Schmitt; G Ramachandra Sridhar; László Vécsei; Zyta Beata Wojszel; Hakan Yaman; Zheng G Zhang; Tali Cukierman-Yaffe
Journal:  J Neural Transm (Vienna)       Date:  2017-08-01       Impact factor: 3.575

3.  Modeling Alzheimer's disease: from past to future.

Authors:  Claudia Saraceno; Stefano Musardo; Elena Marcello; Silvia Pelucchi; Monica Di Luca
Journal:  Front Pharmacol       Date:  2013-06-19       Impact factor: 5.810

4.  Upregulated expression of brain enzymatic markers of arachidonic and docosahexaenoic acid metabolism in a rat model of the metabolic syndrome.

Authors:  Ameer Y Taha; Fei Gao; Epolia Ramadan; Yewon Cheon; Stanley I Rapoport; Hyung-Wook Kim
Journal:  BMC Neurosci       Date:  2012-10-30       Impact factor: 3.288

5.  The novel GLP-1/GIP analogue DA5-CH reduces tau phosphorylation and normalizes theta rhythm in the icv. STZ rat model of AD.

Authors:  Cheng Li; Weizhen Liu; Xiaohui Li; Zijuan Zhang; Huaxin Qi; Shijin Liu; Ningning Yan; Ying Xing; Christian Hölscher; Zhiju Wang
Journal:  Brain Behav       Date:  2020-01-20       Impact factor: 2.708
  5 in total

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