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Literature DB >> 2113566

An in vitro model for cyclosporin A-induced interference of intrathymic clonal elimination.

H Kosaka¹, H Matsubara, S Sogoh, M Ogata, T Hamaoka, H Fujiwara.

Abstract

The effects of cyclosporin A (CsA) on influencing the intrathymic clonal deletion were investigated by using our established thymic stromal cell clone with capacities to express Ia antigens and to produce a unique T cell growth factor. The following were revealed: (a) T cell clone with a given specificity was killed on the Ia+ stromal cell monolayer in the presence of the relevant antigens, a process depending on T cell receptor (TCR) stimulation; and (b) CsA allowed the T cell clone to continuously proliferate even during TCR stimulation by virtue of the stromal cell-derived T cell growth factor. This paper describes an in vitro model of a mechanism by which CsA is responsible for the generation of normally "forbidden" T cell clones.

Entities: Chemical

Mesh：

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Year: 1990 PMID： 2113566 PMCID： PMC2188159 DOI： 10.1084/jem.172.1.395

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

14 in total

10. Cyclosporine-induced autoimmunity. Conditions for expressing disease, requirement for intact thymus, and potency estimates of autoimmune lymphocytes in drug-treated rats.

Authors: R Sorokin; H Kimura; K Schroder; D H Wilson; D B Wilson
Journal: J Exp Med Date: 1986-11-01 Impact factor: 14.307

2 in total

1. NADPH diaphorase-positive dendritic profiles in rat thymus are discrete from autofluorescent cells, immunoreactive for inducible nitric oxide synthase, and show strain-specific abundance differences.

Authors: J E Downing; L Virag; I W Jones
Journal: Immunology Date: 1998-09 Impact factor: 7.397

2. Demonstration of large-scale migration of cortical thymocytes to peripheral lymphoid tissues in cyclosporin A-treated rats.

Authors: H H Zadeh; I Goldschneider
Journal: J Exp Med Date: 1993-07-01 Impact factor: 14.307

2 in total

An in vitro model for cyclosporin A-induced interference of intrathymic clonal elimination.

1. Model for clonal elimination in the thymus.

2. T cell tolerance by clonal elimination in the thymus.

Review 3. The effects of cyclosporin A on the immune system.

4. Use of cyclosporin A in allogeneic bone marrow transplantation in the rat.

5. Thymic stroma-derived T-cell growth factor (TSTGF): II. Biochemical and functional characterization.

6. Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes.

7. Effects of cyclosporine A on T cell development and clonal deletion.

8. Effects of cyclosporine immunosuppression in insulin-dependent diabetes mellitus of recent onset.

9. The effect of cyclosporin A on the adoptive transfer of experimental allergic encephalomyelitis in the Lewis rat.

10. Cyclosporine-induced autoimmunity. Conditions for expressing disease, requirement for intact thymus, and potency estimates of autoimmune lymphocytes in drug-treated rats.

1. NADPH diaphorase-positive dendritic profiles in rat thymus are discrete from autofluorescent cells, immunoreactive for inducible nitric oxide synthase, and show strain-specific abundance differences.

2. Demonstration of large-scale migration of cortical thymocytes to peripheral lymphoid tissues in cyclosporin A-treated rats.