Literature DB >> 21134952

A difficult case of necrotizing fasciitis caused by Acinetobacter baumannii.

Bartolo Corradino1, Francesca Toia, Sara di Lorenzo, Adriana Cordova, Francesco Moschella.   

Abstract

This study reports the case of a 55-year-old woman with diabetes with a necrotizing fasciitis of the right lower limb and the perineum, first admitted at the emergency department for septic shock with cardiac arrest, and later transferred to the department of surgery. Microbiological and histopathological examination confirmed the diagnosis of necrotizing fasciitis caused by Acinetobacter baumannii. A broad-spectrum antibiotic therapy was administered and later readjusted according to the results of microbiological culture. Intensive hemodynamic support was required. Wounds were dressed daily with a 3 percent boric acid solution and a silver sulfadiazine-impregnated dressing. An extensive surgical debridement was promptly performed and repeated until complete control of the infection. Wounds were finally covered with split-thickness skin grafts. The infection was overcome 35 days after admission. The graft take was 100%. Postoperative rehabilitation was required because of the functional limitation of lower limb movements. Follow-up at 6 months showed no functional deficit and an acceptable aesthetic result. Necrotizing fasciitis is a life-threatening disorder, especially in patients with diabetes, whose clinical diagnosis may sometimes be challenging. Early recognition and treatment represent the most important factors influencing survival.

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Year:  2010        PMID: 21134952     DOI: 10.1177/1534734610389598

Source DB:  PubMed          Journal:  Int J Low Extrem Wounds        ISSN: 1534-7346            Impact factor:   2.057


  10 in total

Review 1.  Clinical and Pathophysiological Overview of Acinetobacter Infections: a Century of Challenges.

Authors:  Darren Wong; Travis B Nielsen; Robert A Bonomo; Paul Pantapalangkoor; Brian Luna; Brad Spellberg
Journal:  Clin Microbiol Rev       Date:  2017-01       Impact factor: 26.132

2.  Role of acinetobactin-mediated iron acquisition functions in the interaction of Acinetobacter baumannii strain ATCC 19606T with human lung epithelial cells, Galleria mellonella caterpillars, and mice.

Authors:  Jennifer A Gaddy; Brock A Arivett; Michael J McConnell; Rafael López-Rojas; Jerónimo Pachón; Luis A Actis
Journal:  Infect Immun       Date:  2012-01-09       Impact factor: 3.441

3.  Validation of a novel murine wound model of Acinetobacter baumannii infection.

Authors:  Mitchell G Thompson; Chad C Black; Rebecca L Pavlicek; Cary L Honnold; Matthew C Wise; Yonas A Alamneh; Jay K Moon; Jennifer L Kessler; Yuanzheng Si; Robert Williams; Suleyman Yildirim; Benjamin C Kirkup; Romanza K Green; Eric R Hall; Thomas J Palys; Daniel V Zurawski
Journal:  Antimicrob Agents Chemother       Date:  2013-12-16       Impact factor: 5.191

4.  A fatal case of multidrug resistant acinetobacter necrotizing fasciitis: the changing scary face of nosocomial infection.

Authors:  Nupur Sinha; Masooma Niazi; Dmitry Lvovsky
Journal:  Case Rep Infect Dis       Date:  2014-10-02

5.  Comparing culture and molecular methods for the identification of microorganisms involved in necrotizing soft tissue infections.

Authors:  Vibeke Børsholt Rudkjøbing; Trine Rolighed Thomsen; Yijuan Xu; Rachael Melton-Kreft; Azad Ahmed; Steffen Eickhardt; Thomas Bjarnsholt; Steen Seier Poulsen; Per Halkjær Nielsen; Joshua P Earl; Garth D Ehrlich; Claus Moser
Journal:  BMC Infect Dis       Date:  2016-11-08       Impact factor: 3.090

6.  Mucin acts as a nutrient source and a signal for the differential expression of genes coding for cellular processes and virulence factors in Acinetobacter baumannii.

Authors:  Emily J Ohneck; Brock A Arivett; Steven E Fiester; Cecily R Wood; Maeva L Metz; Gabriella M Simeone; Luis A Actis
Journal:  PLoS One       Date:  2018-01-08       Impact factor: 3.240

7.  Two Acinetobacter baumannii Isolates Obtained From a Fatal Necrotizing Fasciitis Infection Display Distinct Genomic and Phenotypic Characteristics in Comparison to Type Strains.

Authors:  Jennifer T Grier; Brock A Arivett; Maria S Ramírez; Renee J Chosed; Jessica A Bigner; Emily J Ohneck; Maeva L Metz; Cecily R Wood; Sergio Arce; Andrea Tartaro; Ryan F Relich; Luis A Actis; Steven E Fiester
Journal:  Front Cell Infect Microbiol       Date:  2021-04-12       Impact factor: 5.293

8.  Effect of ethanol on differential protein production and expression of potential virulence functions in the opportunistic pathogen Acinetobacter baumannii.

Authors:  Chika C Nwugo; Brock A Arivett; Daniel L Zimbler; Jennifer A Gaddy; Ashley M Richards; Luis A Actis
Journal:  PLoS One       Date:  2012-12-20       Impact factor: 3.240

9.  Facial ulcerations due to Acinetobacter baumannii: Vessel thrombosis with bacterial mycelia.

Authors:  Dong Ming Li; Ting Ting Sun
Journal:  IDCases       Date:  2014-10-25

10.  Fatal Acinetobacter baumanii Necrotizing Fasciitis following Open Reduction Internal Fixation in a Polytrauma Patient.

Authors:  Alexandre Nehme; Nabih I Joukhadar; Elias Saidy; Mohammad Darwiche; Dany K Aouad; Hicham G Abdel Nour
Journal:  Case Rep Infect Dis       Date:  2018-06-21
  10 in total

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