| Literature DB >> 21134749 |
Ramakrishna V S Nirogi1, Amol D Deshpande, Ramasastri Kambhampati, Rajesh Kumar Badange, Laxman Kota, Anand V Daulatabad, Anil K Shinde, Ishtiyaque Ahmad, Vishwottam Kandikere, Pradeep Jayarajan, P K Dubey.
Abstract
N(1)-Arylsulfonyl-3-piperazinyl indole derivatives were designed and identified as a novel class of 5-HT(6) receptors ligands. All the compounds have high affinity and antagonist activity towards 5-HT(6) receptor. The compound 7a (K(i) = 3.4 nM, functional assay IC(50) = 310 nM) shows enhanced cognitive effect when tested in NORT and Morris water maze models. Synthesis, SAR and PK profile of these novel compounds constitute the subject matter of this Letter.Entities:
Mesh：
Substances：
Year: 2010 PMID： 21134749 DOI： 10.1016/j.bmcl.2010.11.001
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823