Literature DB >> 21134746

Potent transglutaminase inhibitors, dithio β-aminoethyl ketones.

Shoichiro Ozaki1, Etsuko Ebisui, Kozo Hamada, Akinobu Z Suzuki, Akiko Terauchi, Katsuhiko Mikoshiba.   

Abstract

Potent transglutaminase inhibitors were obtained from disulfide compounds, cystamine, dimethyl cystine, and dimethyl homocystine. The disulfide bond and thiophene ring play an important role in inhibitory activity of synthesized aryl β-amino ketones.
Copyright © 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID: 21134746     DOI: 10.1016/j.bmcl.2010.10.136

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

Review 1.  Mannich bases in medicinal chemistry and drug design.

Authors:  Gheorghe Roman
Journal:  Eur J Med Chem       Date:  2014-10-30       Impact factor: 6.514

Review 2.  Coeliac Disease - New Pathophysiological Findings and Their Implications for Therapy.

Authors:  Jürgen Stein; Detlef Schuppan
Journal:  Viszeralmedizin       Date:  2014-06
  2 in total

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