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Literature DB >> 2113435

Nitrosoguanidine-induced adaptive repair in Pseudomonas aeruginosa.

Abstract

Error-proof adaptive repair has been demonstrated in Pseudomonas aeruginosa. Cells of actively replicating wild-type Ps. aeruginosa (ATCC27853) and its auxotrophic derivative PAO 286 were subjected to stepwise adaptation (up to 1 microgram ml-1) by nitrosoguanidine (MNNG). Such cells resisted lethal and mutagenic effects of MNNG-challenge (lethal) doses more efficiently than those of nonadapted cultures. Similarly, reactivation of alkylated Pseudomonas phages was enhanced in adapted cells only. Induction of adaptive repair enzymes was sensitive to chloramphenicol (protein synthesis-inhibiting antibiotic) during adaptation treatment only. Protein extract from adapted cells showed increased levels in sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE).

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Year: 1990 PMID： 2113435 DOI： 10.1007/bf00334521

Source DB: PubMed Journal: Curr Genet ISSN： 0172-8083 Impact factor: 3.886

14 in total

1. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors: U K Laemmli
Journal: Nature Date: 1970-08-15 Impact factor: 49.962

2. Enhanced resistance to nitrosoguanidine killing and mutagenesis in a DNA gyrase mutant of Escherichia coli.

Authors: L Chao; D M Tillman
Journal: J Bacteriol Date: 1982-08 Impact factor: 3.490

Review 3. Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli.

Authors: G C Walker
Journal: Microbiol Rev Date: 1984-03

4. A common mechanism for repair of O6-methylguanine and O6-ethylguanine in DNA.

Authors: B Sedgwick; T Lindahl
Journal: J Mol Biol Date: 1982-01-05 Impact factor: 5.469

5. Induction of a DNA glycosylase for N-methylated purines is part of the adaptive response to alkylating agents.

Authors: P Karran; T Hjelmgren; T Lindahl
Journal: Nature Date: 1982-04-22 Impact factor: 49.962

6. Adaptation to alkylation resistance involves the induction of a DNA glycosylase.

Authors: G Evensen; E Seeberg
Journal: Nature Date: 1982-04-22 Impact factor: 49.962

Review 7. Inhibitors of ribosome functions.

Authors: S Pestka
Journal: Annu Rev Microbiol Date: 1971 Impact factor: 15.500

Nitrosoguanidine-induced adaptive repair in Pseudomonas aeruginosa.

1. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

2. Enhanced resistance to nitrosoguanidine killing and mutagenesis in a DNA gyrase mutant of Escherichia coli.

Review 3. Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli.

4. A common mechanism for repair of O6-methylguanine and O6-ethylguanine in DNA.

5. Induction of a DNA glycosylase for N-methylated purines is part of the adaptive response to alkylating agents.

6. Adaptation to alkylation resistance involves the induction of a DNA glycosylase.

Review 7. Inhibitors of ribosome functions.

8. Adaptive response of Micrococcus luteus to alkylating chemicals.

9. Evidence for an adaptive DNA repair pathway in CHO and human skin fibroblast cell lines.

10. Superficial antigens of Campylobacter (Vibrio) fetus: characterization of antiphagocytic component.

1. A weak adaptive response to alkylation damage in Salmonella typhimurium.