Literature DB >> 2113418

Evidence for a role of brain thyrotropin-releasing hormone (TRH) on stress gastric lesion formation in rats.

D E Hernandez1, M E Arredondo, B G Xue, L Jennes.   

Abstract

Specific polyclonal antibodies raised against synthetic thyrotropin-releasing hormone (TRH) infused intracerebroventricularly (ICV) significantly decreased gastric lesions induced by cold restraint stress. The antiulcer effect of immunologic blockade of brain TRH was specific. Normal rabbit serum or antibodies raised against somatostatin, alpha-MSH, Leu-enkephalin, gonadotropin-releasing hormone and atrial natriuretic factor were ineffective. These findings suggest that brain TRH may play an important role in experimental stress ulcer formation.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2113418     DOI： 10.1016/0361-9230(90)90009-o

Source DB:  PubMed          Journal:  Brain Res Bull        ISSN： 0361-9230            Impact factor:   4.077


  6 in total

Review 1.  Role of brainstem TRH/TRH-R1 receptors in the vagal gastric cholinergic response to various stimuli including sham-feeding.

Authors:  Y Taché; H Yang; M Miampamba; V Martinez; P Q Yuan
Journal:  Auton Neurosci       Date:  2006-03-06       Impact factor: 3.145

Review 2.  The amygdala. Emotions and gut functions.

Authors:  P G Henke; A Ray; R M Sullivan
Journal:  Dig Dis Sci       Date:  1991-11       Impact factor: 3.199

3.  Activation of the parapyramidal region in the ventral medulla stimulates gastric acid secretion through vagal pathways in rats.

Authors:  H Yang; P Q Yuan; L Wang; Y Taché
Journal:  Neuroscience       Date:  2000       Impact factor: 3.590

4.  Learning behavior, escape behavior, and depression in an ulcer susceptible rat strain.

Authors:  W P Paré
Journal:  Integr Physiol Behav Sci       Date:  1992 Apr-Jun

5.  CREB/TRH pathway in the central nervous system regulates energy expenditure in response to deprivation of an essential amino acid.

Authors:  T Xia; Q Zhang; Y Xiao; C Wang; J Yu; H Liu; B Liu; Y Zhang; S Chen; Y Liu; Y Chen; F Guo
Journal:  Int J Obes (Lond)       Date:  2014-04-15       Impact factor: 5.095

6.  Effect of cold-restraint stress on immunoreactive thyrotropin-releasing hormone and immunoreactive somatostatin in the rat stomach.

Authors:  H Nagai; K Morise; T Mitsuma; A Furusawa; H Kaneko; K Uchida; H Yamamoto
Journal:  J Gastroenterol       Date:  1995-04       Impact factor: 7.527
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.