| Literature DB >> 21133651 |
Françoise Arnaud1, Anke H Scultetus, Bobby Kim, Ashraful Haque, Biswajit Saha, Savita Nigam, Paula Moon-Massat, Charles Auker, Richard McCarron, Daniel Freilich.
Abstract
Sodium nitrite (NaNO(2)) was evaluated in a 55% EBV hemorrhage swine model to mitigate the increased blood pressure due to HBOC-201. Animals were resuscitated by three 10 ml/kg infusions of either HBOC-201 or Hextend with and without NaNO(2). All vital signs, coagulation and blood chemistry were measured for 2 hr. HBOC-201-vasoconstriction was attenuated only after the first 10.8 μmol/kg NaNO(2) infusion. Complete abolition was obtained with the highest 3 NaNO(2) dose, but side effects were observed. There was no reduction in platelet function due to NaNO(2). NaNO(2) ability to reduce HBOC-201 vasoactivity was transient and 10.8 μmol/kg NaNO(2) seems an acceptable dose for further investigation.Entities:
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Year: 2010 PMID： 21133651 DOI： 10.3109/10731199.2010.533126
Source DB: PubMed Journal: Artif Cells Blood Substit Immobil Biotechnol ISSN： 1073-1199