| Literature DB >> 21133352 |
Sébastien Lemaire1, Ioannis Houpis, Rainer Wechselberger, Jaak Langens, Wim A A Vermeulen, Nico Smets, Ulrike Nettekoven, Youchu Wang, Tingting Xiao, Haisheng Qu, Renmao Liu, Tim H M Jonckers, Pierre Raboisson, Koen Vandyck, Karl M Nilsson, Vittorio Farina.
Abstract
Diastereoselective hydrogenation of 2'-deoxy-2'-exo-methyleneuridine was carried out under homogeneous conditions using a low loading of a chiral Rh catalyst. This, coupled with improvements in the synthesis of the substrate, allowed the smooth pilot plant preparation of the title compound on >10 kg scale.Entities:
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Year: 2010 PMID： 21133352 DOI： 10.1021/jo101822j
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354