Literature DB >> 21131914

Neuro-oncology: Genetic variation in pediatric and adult brain tumors.

Alba A Brandes1, Enrico Franceschi.   

Abstract

Two new studies suggest that pediatric medulloblastomas and high-grade gliomas are genetically different from the same tumors in adults. Age-dependent gene expression might affect tumor biology; therefore, therapies for adult medulloblastomas or gliomas might not produce the same clinical outcomes in pediatric patients, and vice versa.

Entities:  

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Year:  2010        PMID： 21131914     DOI： 10.1038/nrneurol.2010.176

Source DB:  PubMed          Journal:  Nat Rev Neurol        ISSN： 1759-4758            Impact factor:   42.937


  7 in total

1.  Lack of efficacy of bevacizumab plus irinotecan in children with recurrent malignant glioma and diffuse brainstem glioma: a Pediatric Brain Tumor Consortium study.

Authors:  Sridharan Gururangan; Susan N Chi; Tina Young Poussaint; Arzu Onar-Thomas; Richard J Gilbertson; Sridhar Vajapeyam; Henry S Friedman; Roger J Packer; Brian N Rood; James M Boyett; Larry E Kun
Journal:  J Clin Oncol       Date:  2010-05-17       Impact factor: 44.544

2.  Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease.

Authors:  Barbara S Paugh; Chunxu Qu; Chris Jones; Zhaoli Liu; Martyna Adamowicz-Brice; Junyuan Zhang; Dorine A Bax; Beth Coyle; Jennifer Barrow; Darren Hargrave; James Lowe; Amar Gajjar; Wei Zhao; Alberto Broniscer; David W Ellison; Richard G Grundy; Suzanne J Baker
Journal:  J Clin Oncol       Date:  2010-05-17       Impact factor: 44.544

3.  Adult and pediatric medulloblastomas are genetically distinct and require different algorithms for molecular risk stratification.

Authors:  Andrey Korshunov; Marc Remke; Wiebke Werft; Axel Benner; Marina Ryzhova; Hendrik Witt; Dominik Sturm; Andrea Wittmann; Anna Schöttler; Jörg Felsberg; Guido Reifenberger; Stefan Rutkowski; Wolfram Scheurlen; Andreas E Kulozik; Andreas von Deimling; Peter Lichter; Stefan M Pfister
Journal:  J Clin Oncol       Date:  2010-05-17       Impact factor: 44.544

4.  An integrated genomic analysis of human glioblastoma multiforme.

Authors:  D Williams Parsons; Siân Jones; Xiaosong Zhang; Jimmy Cheng-Ho Lin; Rebecca J Leary; Philipp Angenendt; Parminder Mankoo; Hannah Carter; I-Mei Siu; Gary L Gallia; Alessandro Olivi; Roger McLendon; B Ahmed Rasheed; Stephen Keir; Tatiana Nikolskaya; Yuri Nikolsky; Dana A Busam; Hanna Tekleab; Luis A Diaz; James Hartigan; Doug R Smith; Robert L Strausberg; Suely Kazue Nagahashi Marie; Sueli Mieko Oba Shinjo; Hai Yan; Gregory J Riggins; Darell D Bigner; Rachel Karchin; Nick Papadopoulos; Giovanni Parmigiani; Bert Vogelstein; Victor E Velculescu; Kenneth W Kinzler
Journal:  Science       Date:  2008-09-04       Impact factor: 47.728

5.  The treatment of adults with medulloblastoma: a prospective study.

Authors:  Alba A Brandes; Mario Ermani; Pietro Amista; Umberto Basso; Francesca Vastola; Marina Gardiman; Paolo Iuzzolino; Sergio Turazzi; Antonino Rotilio; Lorenzo Volpin; Carlo Mazza; Laura Sainati; Franco Ammannati; Franco Berti
Journal:  Int J Radiat Oncol Biol Phys       Date:  2003-11-01       Impact factor: 7.038

6.  Comprehensive genomic characterization defines human glioblastoma genes and core pathways.

Authors: 
Journal:  Nature       Date:  2008-09-04       Impact factor: 49.962

7.  IDH1 and IDH2 mutations in gliomas.

Authors:  Hai Yan; D Williams Parsons; Genglin Jin; Roger McLendon; B Ahmed Rasheed; Weishi Yuan; Ivan Kos; Ines Batinic-Haberle; Siân Jones; Gregory J Riggins; Henry Friedman; Allan Friedman; David Reardon; James Herndon; Kenneth W Kinzler; Victor E Velculescu; Bert Vogelstein; Darell D Bigner
Journal:  N Engl J Med       Date:  2009-02-19       Impact factor: 176.079
  7 in total
  2 in total

1.  Preradiation Chemotherapy for Adult High-risk Medulloblastoma: A Trial of the ECOG-ACRIN Cancer Research Group (E4397).

Authors:  Paul L Moots; Anne O'Neill; Harold Londer; Minesh Mehta; Deborah T Blumenthal; Geoffrey R Barger; Margaret L Grunnet; Stuart Grossman; Mark R Gilbert; David Schiff
Journal:  Am J Clin Oncol       Date:  2018-06       Impact factor: 2.339

2.  Adjuvant chemotherapy in adult medulloblastoma: is it an option for average-risk patients?

Authors:  E Franceschi; M Bartolotti; A Paccapelo; G Marucci; R Agati; L Volpin; D Danieli; C Ghimenton; M P Gardiman; C Sturiale; R Poggi; M Mascarin; D Balestrini; B Masotto; A A Brandes
Journal:  J Neurooncol       Date:  2016-03-03       Impact factor: 4.130
  2 in total

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