C M Nagle1, F Kolahdooz2, T I Ibiebele3, C M Olsen4, P H Lahmann4, A C Green5, P M Webb3. 1. Gynaecological Cancer Group, Genetics and Population Health Division, Queensland Institute of Medical Research, Brisbane, Australia. Electronic address: Christina.Nagle@qimr.edu.au. 2. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran. 3. Gynaecological Cancer Group, Genetics and Population Health Division, Queensland Institute of Medical Research, Brisbane, Australia. 4. Cancer Control Group. 5. Cancer and Population Studies Group, Genetics and Population Health Division, Queensland Institute of Medical Research, Brisbane, Australia.
Abstract
BACKGROUND: Our objective was to determine the relationship between dietary glycemic load (GL), glycemic index (GI), carbohydrate intake, and ovarian cancer risk in a population-based case-control study. PATIENTS AND METHODS: A self-administered questionnaire was used to collect data on demographic and lifestyle factors, and a food frequency questionnaire was used to collect dietary information from 1366 women with ovarian cancer and 1414 population controls. RESULTS: GL was positively associated with ovarian cancer. The adjusted odds ratio (OR) for the highest versus the lowest quartile of intake was 1.24 [95% confidence interval (CI) 1.00-1.55, P for trend = 0.03]. Fiber intake was inversely associated with risk. The OR comparing women in the highest fiber-intake group with those in the lowest was 0.78 (95% CI 0.62-0.98, P for trend = 0.11). We found no association between GI, carbohydrate intake, and ovarian cancer. In analyses stratified by body mass index, the risk estimates for GL, carbohydrate, and sugar were higher among overweight/obese women; however, the interaction term was only significant for sugar (P for interaction = 0.004). CONCLUSIONS: Our results suggest that diets with a high GL may increase the risk of ovarian cancer, particularly among overweight/obese women, and a high intake of fiber may provide modest protection.
BACKGROUND: Our objective was to determine the relationship between dietary glycemic load (GL), glycemic index (GI), carbohydrate intake, and ovarian cancer risk in a population-based case-control study. PATIENTS AND METHODS: A self-administered questionnaire was used to collect data on demographic and lifestyle factors, and a food frequency questionnaire was used to collect dietary information from 1366 women with ovarian cancer and 1414 population controls. RESULTS: GL was positively associated with ovarian cancer. The adjusted odds ratio (OR) for the highest versus the lowest quartile of intake was 1.24 [95% confidence interval (CI) 1.00-1.55, P for trend = 0.03]. Fiber intake was inversely associated with risk. The OR comparing women in the highest fiber-intake group with those in the lowest was 0.78 (95% CI 0.62-0.98, P for trend = 0.11). We found no association between GI, carbohydrate intake, and ovarian cancer. In analyses stratified by body mass index, the risk estimates for GL, carbohydrate, and sugar were higher among overweight/obesewomen; however, the interaction term was only significant for sugar (P for interaction = 0.004). CONCLUSIONS: Our results suggest that diets with a high GL may increase the risk of ovarian cancer, particularly among overweight/obesewomen, and a high intake of fiber may provide modest protection.
Authors: Nour Makarem; Elisa V Bandera; Yong Lin; Paul F Jacques; Richard B Hayes; Niyati Parekh Journal: Br J Nutr Date: 2017-06-29 Impact factor: 3.718
Authors: Lauren C Peres; Elisa V Bandera; Bo Qin; Kristin A Guertin; Nitin Shivappa; James R Hebert; Sarah E Abbott; Anthony J Alberg; Jill Barnholtz-Sloan; Melissa Bondy; Michele L Cote; Ellen Funkhouser; Patricia G Moorman; Edward S Peters; Ann G Schwartz; Paul D Terry; Fabian Camacho; Frances Wang; Joellen M Schildkraut Journal: Int J Cancer Date: 2016-11-14 Impact factor: 7.396
Authors: Stephanie C Melkonian; Carrie R Daniel; Yuanqing Ye; Jeanne A Pierzynski; Jack A Roth; Xifeng Wu Journal: Cancer Epidemiol Biomarkers Prev Date: 2016-03 Impact factor: 4.254
Authors: Bo Qin; Patricia G Moorman; Anthony J Alberg; Jill S Barnholtz-Sloan; Melissa Bondy; Michele L Cote; Ellen Funkhouser; Edward S Peters; Ann G Schwartz; Paul Terry; Joellen M Schildkraut; Elisa V Bandera Journal: Br J Nutr Date: 2015-12-16 Impact factor: 3.718
Authors: Melony G King; Sara H Olson; Lisa Paddock; Urmila Chandran; Kitaw Demissie; Shou-En Lu; Niyati Parekh; Lorna Rodriguez-Rodriguez; Elisa V Bandera Journal: BMC Cancer Date: 2013-02-27 Impact factor: 4.430
Authors: Mary C Playdon; Christina M Nagle; Torukiri I Ibiebele; Leah M Ferrucci; Melinda M Protani; Jonathan Carter; Simon E Hyde; Deborah Neesham; James L Nicklin; Susan T Mayne; Penelope M Webb Journal: Br J Cancer Date: 2017-05-02 Impact factor: 7.640