BACKGROUND: Persons with cystic fibrosis (CF) who tend to be hospitalized have poorer overall survival and quality of life. Whether differences exist in hospitalization rates between males and females with CF is unknown. The objective was to assess sex-specific differences in hospitalization rates after adjusting for clinically important factors within a universal health care system. METHODS: A provincial-based longitudinal study using national CF registry data linked to health administrative databases examined differences in annual hospitalization rates estimated by Poisson regression using generalized estimating equations with adjustment for markers of CF disease severity. RESULTS: Among those aged 7 to 19 years, the RR of respiratory-related annual hospitalizations among females vs. males was 1.38 (95% CI 1.11-1.73). Among those over 19 years, the corresponding RR was 1.30 (95% CI 1.06-1.59). CONCLUSIONS: Females affected by CF are at a higher risk of respiratory-related hospitalization, which may extend beyond classic clinical measures of disease severity.
BACKGROUND:Persons with cystic fibrosis (CF) who tend to be hospitalized have poorer overall survival and quality of life. Whether differences exist in hospitalization rates between males and females with CF is unknown. The objective was to assess sex-specific differences in hospitalization rates after adjusting for clinically important factors within a universal health care system. METHODS: A provincial-based longitudinal study using national CF registry data linked to health administrative databases examined differences in annual hospitalization rates estimated by Poisson regression using generalized estimating equations with adjustment for markers of CF disease severity. RESULTS: Among those aged 7 to 19 years, the RR of respiratory-related annual hospitalizations among females vs. males was 1.38 (95% CI 1.11-1.73). Among those over 19 years, the corresponding RR was 1.30 (95% CI 1.06-1.59). CONCLUSIONS: Females affected by CF are at a higher risk of respiratory-related hospitalization, which may extend beyond classic clinical measures of disease severity.
Authors: Sara W Carson; Kevin Psoter; Kirsten Koehler; Karen R Siklosi; Kristina Montemayor; Alexandra Toporek; Natalie E West; Noah Lechtzin; Nadia N Hansel; Joseph M Collaco; Christian A Merlo Journal: J Cyst Fibros Date: 2021-09-13 Impact factor: 5.482
Authors: Bruce C Trapnell; Su Chen; Rupal Khurmi; Amit Bodhani; Mudra Kapoor; Mark Haupt Journal: Chron Respir Dis Date: 2020 Jan-Dec Impact factor: 2.444