Literature DB >> 21130660

Identification of 3-phenylaminoquinolinium and 3-phenylaminopyridinium salts as new agents against opportunistic fungal pathogens.

Tryphon K Mazu1, Jagan R Etukala, Xue Y Zhu, Melissa R Jacob, Shabana I Khan, Larry A Walker, Seth Y Ablordeppey.   

Abstract

Previous studies on the indoloquinoline alkaloid, cryptolepine (2), revealed that it has antii-nfective properties among other activities. Using Structure-activity relationship (SAR) techniques, several ring-opened analogs of cryptolepine (3-phenylaminopyridinium and 3-phenylaminoquinolinium derivatives) were designed to improve the potency and lower the cytotoxicity shown by several of the precursor agents. Results indicate that these ring-opened analogs constitute new anti-infective agents with over a 100-fold potency and several fold lower cytotoxicity than cryptolepine from which they are derived. Published by Elsevier Ltd.

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Year:  2010        PMID： 21130660      PMCID： PMC3014406          DOI： 10.1016/j.bmc.2010.10.065

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  27 in total

1.  Probing the N-5 region of the indoloquinoline alkaloid, cryptolepine for anticryptococcal activity.

Authors:  S Y Ablordeppey; P Fan; A M Clark; A Nimrod
Journal:  Bioorg Med Chem       Date:  1999-02       Impact factor: 3.641

2.  Rapid, low-technology MIC determination with clinical Mycobacterium tuberculosis isolates by using the microplate Alamar Blue assay.

Authors:  S G Franzblau; R S Witzig; J C McLaughlin; P Torres; G Madico; A Hernandez; M T Degnan; M B Cook; V K Quenzer; R M Ferguson; R H Gilman
Journal:  J Clin Microbiol       Date:  1998-02       Impact factor: 5.948

3.  The antimalarial and cytotoxic drug cryptolepine intercalates into DNA at cytosine-cytosine sites.

Authors:  John N Lisgarten; Miquel Coll; Jose Portugal; Colin W Wright; Juan Aymami
Journal:  Nat Struct Biol       Date:  2002-01

4.  Benzothieno[3,2-b]quinolinium and 3-(phenylthio)quinolinium compounds: Synthesis and evaluation against opportunistic fungal pathogens.

Authors:  Comfort A Boateng; Suresh V K Eyunni; Xue Y Zhu; Jagan R Etukala; Barbara A Bricker; M K Ashfaq; Melissa R Jacob; Shabana I Khan; Larry A Walker; Seth Y Ablordeppey
Journal:  Bioorg Med Chem       Date:  2010-11-10       Impact factor: 3.641

5.  Identification of bis-quindolines as new antiinfective agents.

Authors:  Leroy G Mardenborough; Xue Y Zhu; Pincheng Fan; Melissa R Jacob; Shabana I Khan; Larry A Walker; Seth Y Ablordeppey
Journal:  Bioorg Med Chem       Date:  2005-06-02       Impact factor: 3.641

Review 6.  Systemic antifungal agents against AIDS-related opportunistic infections: current status and emerging drugs in development.

Authors:  S Y Ablordeppey; P Fan; J H Ablordeppey; L Mardenborough
Journal:  Curr Med Chem       Date:  1999-12       Impact factor: 4.530

7.  The popular herbal antimalarial, extract of Cryptolepis sanguinolenta, is potently cytotoxic.

Authors:  Charles Ansah; Nigel J Gooderham
Journal:  Toxicol Sci       Date:  2002-12       Impact factor: 4.849

8.  Interactions of cryptolepine and neocryptolepine with unusual DNA structures.

Authors:  Lionel Guittat; Patrizia Alberti; Frédéric Rosu; Sabine Van Miert; Emilie Thetiot; Luc Pieters; Valérie Gabelica; Edwin De Pauw; Alexandre Ottaviani; Jean-François Riou; Jean-Louis Mergny
Journal:  Biochimie       Date:  2003-05       Impact factor: 4.079

Review 9.  Fungi pathogenic to humans: molecular bases of virulence of Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus.

Authors:  Justyna Karkowska-Kuleta; Maria Rapala-Kozik; Andrzej Kozik
Journal:  Acta Biochim Pol       Date:  2009-06-18       Impact factor: 2.149

10.  Cryptococcus neoformans strains and infection in apparently immunocompetent patients, China.

Authors:  Jianghan Chen; Ashok Varma; Mara R Diaz; Anastasia P Litvintseva; Kurt K Wollenberg; Kyung J Kwon-Chung
Journal:  Emerg Infect Dis       Date:  2008-05       Impact factor: 6.883
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  4 in total

1.  δ-Carbolines and their ring-opened analogs: synthesis and evaluation against fungal and bacterial opportunistic pathogens.

Authors:  Tryphon K Mazu; Jagan R Etukala; Melissa R Jacob; Shabana I Khan; Larry A Walker; Seth Y Ablordeppey
Journal:  Eur J Med Chem       Date:  2011-03-17       Impact factor: 6.514

2.  Synthesis and biological evaluation of tricyclic guanidine analogues of batzelladine K for antimalarial, antileishmanial, antibacterial, antifungal, and anti-HIV activities.

Authors:  Nafees Ahmed; Keyur G Brahmbhatt; Shabana I Khan; Melissa Jacob; Babu L Tekwani; Sudeep Sabde; Debashis Mitra; Inder P Singh; Ikhlas A Khan; Kamlesh K Bhutani
Journal:  Chem Biol Drug Des       Date:  2013-04       Impact factor: 2.817

Review 3.  The Mechanistic Targets of Antifungal Agents: An Overview.

Authors:  Tryphon K Mazu; Barbara A Bricker; Hernan Flores-Rozas; Seth Y Ablordeppey
Journal:  Mini Rev Med Chem       Date:  2016       Impact factor: 3.862

4.  CoMFA studies and in vitro evaluation of some 3-substituted benzylthio quinolinium salts as anticryptococcal agents.

Authors:  Sidney Bolden; Comfort A Boateng; Xue Y Zhu; Jagan R Etukala; Suresh K Eyunni; Melissa R Jacob; Shabana I Khan; Seth Y Ablordeppey
Journal:  Bioorg Med Chem       Date:  2013-09-03       Impact factor: 3.641
  4 in total

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