| Literature DB >> 21130542 |
Seif-Eldin N Ayyad1, Mohamed S Makki, Nazeeha S Al-Kayal, Salim A Basaif, Kalid O El-Foty, Abdullah M Asiri, Walied M Alarif, Farid A Badria.
Abstract
Three new diterpenes Amijiol acetate (3), dolabellane, Dolabellatrienol (4), and dolastane, Amijiol-7, 10-diacetate (9) were isolated together with the previously described Pachydictyol A (1), Isopachydictyol A (2), 8β-hydroxypachydictyol A (5), Amijiol (6), Isodictyohemiacetal (7) and Dictyol C (8) from the Red Sea brown alga Dictyota dichotoma var. implexa. The structures and relative stereochemistry of the new diterpenoids were proposed on the basis of their spectral data. Compounds 3 and 9 have potent activity against DNA damage, cytotoxicity against WI-38, HepG2, and MCF-7 cell lines, and antioxidant using ABTS and erythrocytes hemolysis.Entities:
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Year: 2010 PMID： 21130542 DOI： 10.1016/j.ejmech.2010.10.033
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514