OBJECTIVE: To report a novel fertility preservation strategy in a woman with recurrent serous borderline ovarian tumor in the conserved ovary involving ex-vivo retrieval of in vivo matured oocytes and subsequent embryo cryopreservation. DESIGN: Case report. SETTING: Tertiary infertility care unit. PATIENT(S): A 27-year-old woman presented for follow-up visit with a history of borderline serous adenocarcinoma treated conservatively with left oophorectomy and fertility-sparing laparoscopic staging. Ultrasound scan revealed a recurrent disease in the right ovary. INTERVENTION(S): Ex-vivo retrieval of mature oocytes after ovarian stimulation. MAIN OUTCOME MEASURE(S): Fertility preservation. RESULT(S): The patient underwent ovarian stimulation followed by a laparotomy and oophorectomy on the day of oocyte retrieval. A puncture of the follicles was performed in the operating theatre with a maximum ischemia time of 14 minutes. Eleven mature oocytes were aspirating, resulting in seven zygotes for cryopreservation. CONCLUSION(S): Mature oocytes can be successfully retrieved ex-vivo from the oophorectomy specimen after a controlled ovarian hyperstimulation (COH) protocol. This method provides a possible strategy for fertility preservation in patients with recurrent ovarian cancer without the risk of cancer cells spillage associated with the standard transvaginal oocyte retrieval.
OBJECTIVE: To report a novel fertility preservation strategy in a woman with recurrent serous borderline ovarian tumor in the conserved ovary involving ex-vivo retrieval of in vivo matured oocytes and subsequent embryo cryopreservation. DESIGN: Case report. SETTING: Tertiary infertility care unit. PATIENT(S): A 27-year-old woman presented for follow-up visit with a history of borderline serous adenocarcinoma treated conservatively with left oophorectomy and fertility-sparing laparoscopic staging. Ultrasound scan revealed a recurrent disease in the right ovary. INTERVENTION(S): Ex-vivo retrieval of mature oocytes after ovarian stimulation. MAIN OUTCOME MEASURE(S): Fertility preservation. RESULT(S): The patient underwent ovarian stimulation followed by a laparotomy and oophorectomy on the day of oocyte retrieval. A puncture of the follicles was performed in the operating theatre with a maximum ischemia time of 14 minutes. Eleven mature oocytes were aspirating, resulting in seven zygotes for cryopreservation. CONCLUSION(S): Mature oocytes can be successfully retrieved ex-vivo from the oophorectomy specimen after a controlled ovarian hyperstimulation (COH) protocol. This method provides a possible strategy for fertility preservation in patients with recurrent ovarian cancer without the risk of cancer cells spillage associated with the standard transvaginal oocyte retrieval.
Authors: Enrique Perez de la Blanca; Maria Fuensanta Fernandez-Perez; Elena Del Mar Martin-Diaz; Manuel Lozano; Marta Garcia-Sanchez; Carolina Monedero Journal: J Reprod Infertil Date: 2018 Jul-Sep
Authors: Fereshteh Safian; Mohammad Ali Khalili; Mojgan Karimi-Zarchi; Mehdi Mohsenzadeh; Sareh Ashourzadeh; Marjan Omidi Journal: Iran J Reprod Med Date: 2015-08