Literature DB >> 21130414

Is there a role for differentiating therapy in non-APL AML?

H Phillip Koeffler1.   

Abstract

Differentiation therapy with all-trans retinoic acid has been a very successful therapeutic strategy in acute promyelocytic leukemia (APL), but the value of differentiation therapy in acute myeloid leukemia (AML) remains to be determined. A number of current treatments, such as tyrosine kinase inhibitors, cytokines, and epigenetic agents, induce differentiation of leukemic cells to some extent, but differentiation is not the main goal of these treatments. Forcing expression of certain transcription factors, such as C/EBP, has also been useful in inducing differentiation in cell lines and in murine models, but an effective way to force expression of these genes in humans is yet to be discovered.
Copyright © 2010. Published by Elsevier Ltd.

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Year:  2010        PMID： 21130414      PMCID： PMC5884682          DOI： 10.1016/j.beha.2010.09.014

Source DB:  PubMed          Journal:  Best Pract Res Clin Haematol        ISSN： 1521-6926            Impact factor:   3.020


  32 in total

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  4 in total

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