Literature DB >> 21128591

4-[18F]fluoroglutamic acid (BAY 85-8050), a new amino acid radiotracer for PET imaging of tumors: synthesis and in vitro characterization.

Raisa N Krasikova1, Olga F Kuznetsova, Olga S Fedorova, Yuri N Belokon, Viktor I Maleev, Linjing Mu, Simon Ametamey, P August Schubiger, Matthias Friebe, Mathias Berndt, Norman Koglin, Andre Mueller, Keith Graham, Lutz Lehmann, Ludger M Dinkelborg.   

Abstract

There is a high demand for tumor specific PET tracers in oncology imaging. Besides glucose, certain amino acids also serve as energy sources and anabolic precursors for tumors. Therefore, (18)F-labeled amino acids are interesting probes for tumor specific PET imaging. As glutamine and glutamate play a key role in the adapted intermediary metabolism of tumors, the radiosynthesis of 4-[(18)F]fluoro l-glutamic acid (BAY 85-8050) as a new specific PET tracer was established. Cell-uptake studies revealed specific tumor cell accumulation.

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Year:  2010        PMID： 21128591     DOI： 10.1021/jm101068q

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  14 in total

1.  18F-AFETP, 18F-FET, and 18F-FDG imaging of mouse DBT gliomas.

Authors:  Kiran Kumar Solingapuram Sai; Chaofeng Huang; Liya Yuan; Dong Zhou; David Piwnica-Worms; Joel R Garbow; John A Engelbach; Robert H Mach; Keith M Rich; Jonathan McConathy
Journal:  J Nucl Med       Date:  2013-05-06       Impact factor: 10.057

Review 2.  Lipids and prostate cancer.

Authors:  Janel Suburu; Yong Q Chen
Journal:  Prostaglandins Other Lipid Mediat       Date:  2012-04-05       Impact factor: 3.072

3.  Preclinical evaluation of BAY 1075553, a novel (18)F-labelled inhibitor of prostate-specific membrane antigen for PET imaging of prostate cancer.

Authors:  Ralf Lesche; Georg Kettschau; Alexey V Gromov; Niels Böhnke; Sandra Borkowski; Ursula Mönning; Christa Hegele-Hartung; Olaf Döhr; Ludger M Dinkelborg; Keith Graham
Journal:  Eur J Nucl Med Mol Imaging       Date:  2013-08-17       Impact factor: 9.236

Review 4.  Role of glutamine in cancer: therapeutic and imaging implications.

Authors:  Kartik N Rajagopalan; Ralph J DeBerardinis
Journal:  J Nucl Med       Date:  2011-06-16       Impact factor: 10.057

Review 5.  Pathogen-Specific Bacterial Imaging in Nuclear Medicine.

Authors:  Alvaro A Ordonez; Sanjay K Jain
Journal:  Semin Nucl Med       Date:  2017-12-14       Impact factor: 4.446

6.  Biodistribution and radiation dosimetry in healthy volunteers of a novel tumour-specific probe for PET/CT imaging: BAY 85-8050.

Authors:  Kamilla Smolarz; Bernd Joachim Krause; Frank Philipp Graner; Franziska Martina Wagner; Hans-Jürgen Wester; Tina Sell; Claudia Bacher-Stier; Lüder Fels; Ludger Dinkelborg; Markus Schwaiger
Journal:  Eur J Nucl Med Mol Imaging       Date:  2013-07-23       Impact factor: 9.236

7.  Intracardiac Metastases Detected by 18F-FSPG PET/CT.

Authors:  Meaghan A Magarik; Ronald C Walker; Jill Gilbert; H Charles Manning; Pierre P Massion
Journal:  Clin Nucl Med       Date:  2018-01       Impact factor: 7.794

8.  Targeting SLC1a5-mediated glutamine dependence in non-small cell lung cancer.

Authors:  Mohamed Hassanein; Jun Qian; Megan D Hoeksema; Jing Wang; Marie Jacobovitz; Xiangming Ji; Fredrick T Harris; Bradford K Harris; Kelli L Boyd; Heidi Chen; Rosana Eisenberg; Pierre P Massion
Journal:  Int J Cancer       Date:  2015-05-06       Impact factor: 7.396

Review 9.  Imaging tumor metabolism using positron emission tomography.

Authors:  David Y Lewis; Dmitry Soloviev; Kevin M Brindle
Journal:  Cancer J       Date:  2015 Mar-Apr       Impact factor: 3.360

10.  Radiosynthesis and biological evaluation of N-[18F]labeled glutamic acid as a tumor metabolic imaging tracer.

Authors:  Kongzhen Hu; Kan Du; Ganghua Tang; Shaobo Yao; Hongliang Wang; Xiang Liang; Baoguo Yao; Tingting Huang; Linquan Zang
Journal:  PLoS One       Date:  2014-03-28       Impact factor: 3.240
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