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Literature DB >> 21128305

Fgfr1 and the IIIc isoform of Fgfr2 play critical roles in the metanephric mesenchyme mediating early inductive events in kidney development.

Sunder Sims-Lucas¹, Brian Cusack, Jeffrey Baust, Veraragavan P Eswarakumar, Hagiwara Masatoshi, Akihide Takeuchi, Carlton M Bates.

Abstract

Fibroblast growth factor receptors (Fgfrs) have critical roles in kidney development. FgfrIIIb is thought to act in epithelium, while FgfrIIIc functions in mesenchyme. We aimed to determine roles of Fgfr2IIIc in kidney development. Mice with deletion of Fgfr2IIIc (Fgfr2IIIc-/-) had normal kidneys. Combination of Fgfr2IIIc-/- with conditional deletion of Fgfr1 in metanephric mesenchyme (MM) (Fgfr1(Mes-/-)Fgfr2IIIc-/-) had small but identifiable MM at embryonic day (E) 10.5, expressing mesenchymal markers including Eya1, Six2, Pax2, and Gdnf (unlike Fgfr1/2(Mes-/-) mice that have no obvious MM). E11.5 Fgfr1(Mes-/-)Fgfr2IIIc-/- mice had rudimentary MM expressing only Eya1. Control, Fgfr2IIIc-/-, and Fgfr1(Mes-/-)Fgfr2IIIc-/- kidney mesenchymal tissues also express Fgfr2IIIb. In ureteric lineages, E10.5 Fgfr1(Mes-/-)Fgfr2IIIc-/- embryos had ureteric outgrowth (sometimes multiple buds); however, by E11.5 Gdnf absence lead to no ureteric elongation or branching (similar to Fgfr1/2(Mes-/-) mice). Beyond E12.5, Fgfr1(Mes-/-)Fgfr2IIIc-/- mice had no renal tissue. In conclusion, Fgfr2IIIc and Fgfr1 in kidney mesenchyme (together) are critical for normal early renal development.

Entities: Chemical Disease Gene Species

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Year: 2011 PMID： 21128305 PMCID： PMC3093196 DOI： 10.1002/dvdy.22501

Source DB: PubMed Journal: Dev Dyn ISSN： 1058-8388 Impact factor: 3.780

36 in total

Review 1. Kidney morphogenesis: cellular and molecular regulation.

Authors: S Kuure; R Vuolteenaho; S Vainio
Journal: Mech Dev Date: 2000-03-15 Impact factor: 1.882

Review 2. Fibroblast growth factors, their receptors and signaling.

Authors: C J Powers; S W McLeskey; A Wellstein
Journal: Endocr Relat Cancer Date: 2000-09 Impact factor: 5.678

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Authors: David Hains; Sunder Sims-Lucas; Kayle Kish; Monalee Saha; Kirk McHugh; Carlton M Bates
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Review 4. Advances in early kidney specification, development and patterning.

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Review 5. GDNF and its receptors in the regulation of the ureteric branching.

Authors: H Sariola; M Saarma
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6. High incidence of vesicoureteral reflux in mice with Fgfr2 deletion in kidney mesenchyma.

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Review 7. Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development.

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Review 8. Fibroblast growth factor signalling: from development to cancer.

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10. Deletion of Frs2alpha from the ureteric epithelium causes renal hypoplasia.

Authors: Sunder Sims-Lucas; Luise Cullen-McEwen; Veraragavan P Eswarakumar; David Hains; Kayle Kish; Brian Becknell; Jue Zhang; John F Bertram; Fen Wang; Carlton M Bates
Journal: Am J Physiol Renal Physiol Date: 2009-09-09

27 in total

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Authors: Valeria Di Giovanni; Kenneth A Walker; Daniel Bushnell; Caitlin Schaefer; Sunder Sims-Lucas; Pawan Puri; Carlton M Bates
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4. Bim gene dosage is critical in modulating nephron progenitor survival in the absence of microRNAs during kidney development.

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