BACKGROUND: The tropomyosin-related kinase B (TrkB)/brain-derived neurotrophic factor system has been associated with psychiatric disorders, and animal models of defects in this system suggest that it might have a particular role in anxiety. METHODS: DNA sequencing and cloning were used to identify a mutation in TrkB, and four different cell lines were used to assess functionality. Clinical samples were from a 22-year longitudinal cohort representative of the Quebec general population (n = 640 subjects), randomly selected when they were in kindergarten. Anxiety-related traits were measured with the Social Behaviour Questionnaire, the Diagnostic Assessment of Personality Pathology-Brief Questionnaire, and the Diagnostic Interview Schedule for DSM-IIIR. RESULTS: An 11 base pair deletion in TrkB is significantly associated with increases in anxiety traits during childhood and the development of anxiety disorders in adulthood. We found that this deletion impaired transcription in some human cell lines. CONCLUSIONS: The identification of this deletion provides additional support for the role of TrkB in modulating anxiety-related traits in human.
BACKGROUND: The tropomyosin-related kinase B (TrkB)/brain-derived neurotrophic factor system has been associated with psychiatric disorders, and animal models of defects in this system suggest that it might have a particular role in anxiety. METHODS: DNA sequencing and cloning were used to identify a mutation in TrkB, and four different cell lines were used to assess functionality. Clinical samples were from a 22-year longitudinal cohort representative of the Quebec general population (n = 640 subjects), randomly selected when they were in kindergarten. Anxiety-related traits were measured with the Social Behaviour Questionnaire, the Diagnostic Assessment of Personality Pathology-Brief Questionnaire, and the Diagnostic Interview Schedule for DSM-IIIR. RESULTS: An 11 base pair deletion in TrkB is significantly associated with increases in anxiety traits during childhood and the development of anxiety disorders in adulthood. We found that this deletion impaired transcription in some human cell lines. CONCLUSIONS: The identification of this deletion provides additional support for the role of TrkB in modulating anxiety-related traits in human.
Authors: Vanja Vukojevic; David Coynel; Navid R Ghaffari; Virginie Freytag; Thomas Elbert; Iris-Tatjana Kolassa; Sarah Wilker; James L McGaugh; Andreas Papassotiropoulos; Dominique J-F de Quervain Journal: Proc Natl Acad Sci U S A Date: 2020-08-17 Impact factor: 11.205
Authors: Stefan Walter; M Maria Glymour; Karestan Koenen; Liming Liang; Eric J Tchetgen Tchetgen; Marilyn Cornelis; Shun-Chiao Chang; Eric Rimm; Ichiro Kawachi; Laura D Kubzansky Journal: PLoS One Date: 2013-11-20 Impact factor: 3.240
Authors: Nina N Karpova; Jesse Saku Olavi Lindholm; Natalia Kulesskaya; Natalia Onishchenko; Marie Vahter; Dina Popova; Sandra Ceccatelli; Eero Castrén Journal: Front Behav Neurosci Date: 2014-09-12 Impact factor: 3.558