Literature DB >> 2112523

Significant increase of 8-hydroxydeoxyguanosine in liver DNA of rats following short-term exposure to the peroxisome proliferators di(2-ethylhexyl)phthalate and di(2-ethylhexyl)adipate.

A Takagi1, K Sai, T Umemura, R Hasegawa, Y Kurokawa.   

Abstract

8-Hydroxydeoxyguanosine (8-OH-dG) levels were examined in liver and kidney DNA after di(2-ethylhexyl)phthalate (DEHP), di(2-ethylhexyl)adipate (DEHA) and phthalic anhydride administration to male 6-week-old F-344 rats in the diet at concentrations of 1.2, 2.5 and 1.5%, respectively. Significant increases in 8-OH-dG levels were observed only in the liver (target organ of DEHP and DEHA carcinogenesis) DNA after 1 and 2 weeks of treatment with DEHP and DEHA, respectively. The results suggest the involvement of oxidative DNA damage in hepatocarcinogenesis by peroxisome proliferators.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2112523      PMCID： PMC5918022          DOI： 10.1111/j.1349-7006.1990.tb02551.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


di(2‐ethylhexyl)phthalate di(2‐ethylhexyl)adipate phthalic anhydride 8‐hydroxydeoxyguanosine
  17 in total

Review 1.  Chemically induced proliferation of peroxisomes: implications for risk assessment.

Authors:  W T Stott
Journal:  Regul Toxicol Pharmacol       Date:  1988-06       Impact factor: 3.271

2.  Formation of 8-hydroxydeoxyguanosine in liver DNA of rats following long-term exposure to a peroxisome proliferator.

Authors:  H Kasai; Y Okada; S Nishimura; M S Rao; J K Reddy
Journal:  Cancer Res       Date:  1989-05-15       Impact factor: 12.701

3.  Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

Authors:  C Richter; J W Park; B N Ames
Journal:  Proc Natl Acad Sci U S A       Date:  1988-09       Impact factor: 11.205

Review 4.  Peroxisome proliferation and hepatocarcinogenesis.

Authors:  M S Rao; J K Reddy
Journal:  Carcinogenesis       Date:  1987-05       Impact factor: 4.944

5.  Excessive accumulation of autofluorescent lipofuscin in the liver during hepatocarcinogenesis by methyl clofenapate and other hypolipidemic peroxisome proliferators.

Authors:  J K Reddy; N D Lalwani; M K Reddy; S A Qureshi
Journal:  Cancer Res       Date:  1982-01       Impact factor: 12.701

6.  Hepatic peroxisome (microbody) proliferation in rats fed plasticizers and related compounds.

Authors:  D E Moody; J K Reddy
Journal:  Toxicol Appl Pharmacol       Date:  1978-08       Impact factor: 4.219

7.  Increased hydroxyl radical production in liver peroxisomal fractions from rats treated with peroxisome proliferators.

Authors:  B M Elliott; N J Dodd; C R Elcombe
Journal:  Carcinogenesis       Date:  1986-05       Impact factor: 4.944

8.  Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents.

Authors:  H Kasai; S Nishimura
Journal:  Nucleic Acids Res       Date:  1984-02-24       Impact factor: 16.971

9.  32P-postlabeling analysis of peroxisome proliferator-DNA adduct formation in rat liver in vivo and hepatocytes in vitro.

Authors:  R C Gupta; S K Goel; K Earley; B Singh; J K Reddy
Journal:  Carcinogenesis       Date:  1985-06       Impact factor: 4.944

10.  Carcinogenic potential of phthalic acid esters and related compounds: structure-activity relationships.

Authors:  W M Kluwe
Journal:  Environ Health Perspect       Date:  1986-03       Impact factor: 9.031
View more
  11 in total

1.  Increased urinary 8-hydroxy-2'-deoxyguanosine levels in workers exposed to di-(2-ethylhexyl) phthalate in a waste plastic recycling site in China.

Authors:  Qian Wang; Li Wang; Xi Chen; Kai Min Rao; Shao You Lu; Sheng Tao Ma; Pu Jiang; Dan Zheng; Shun Qing Xu; Hong Yan Zheng; Jian Shu Wang; Zhi Qiang Yu; Rong Zhang; Yong Tao; Jing Yuan
Journal:  Environ Sci Pollut Res Int       Date:  2011-02-06       Impact factor: 4.223

Review 2.  Modes of action and species-specific effects of di-(2-ethylhexyl)phthalate in the liver.

Authors:  Ivan Rusyn; Jeffrey M Peters; Michael L Cunningham
Journal:  Crit Rev Toxicol       Date:  2006-05       Impact factor: 5.635

3.  In vitro acute exposure to DEHP affects oocyte meiotic maturation, energy and oxidative stress parameters in a large animal model.

Authors:  Barbara Ambruosi; Manuel Filioli Uranio; Anna Maria Sardanelli; Paola Pocar; Nicola Antonio Martino; Maria Stefania Paternoster; Francesca Amati; Maria Elena Dell'Aquila
Journal:  PLoS One       Date:  2011-11-04       Impact factor: 3.240

4.  Promotion of rat hepatocarcinogenesis by dimethylarsinic acid: association with elevated ornithine decarboxylase activity and formation of 8-hydroxydeoxyguanosine in the liver.

Authors:  H Wanibuchi; T Hori; V Meenakshi; T Ichihara; S Yamamoto; Y Yano; S Otani; D Nakae; Y Konishi; S Fukushima
Journal:  Jpn J Cancer Res       Date:  1997-12

Review 5.  Anomalous nonidentity between Salmonella genotoxicants and rodent carcinogens: nongenotoxic carcinogens and genotoxic noncarcinogens.

Authors:  K Yoshikawa
Journal:  Environ Health Perspect       Date:  1996-01       Impact factor: 9.031

6.  The protective role of glutathione, cysteine and vitamin C against oxidative DNA damage induced in rat kidney by potassium bromate.

Authors:  K Sai; T Umemura; A Takagi; R Hasegawa; Y Kurokawa
Journal:  Jpn J Cancer Res       Date:  1992-01

7.  Different roles of 8-hydroxyguanine formation and 2-thiobarbituric acid-reacting substance generation in the early phase of liver carcinogenesis induced by a choline-deficient, L-amino acid-defined diet in rats.

Authors:  D Nakae; Y Mizumoto; H Yoshiji; N Andoh; K Horiguchi; K Shiraiwa; E Kobayashi; T Endoh; N Shimoji; K Tamura
Journal:  Jpn J Cancer Res       Date:  1994-05

8.  Prevention by methionine of enhancement of hepatocarcinogenesis by coadministration of a choline-deficient L-amino acid-defined diet and ethionine in rats.

Authors:  T Tsujiuchi; E Kobayashi; D Nakae; Y Mizumoto; N Andoh; H Kitada; K Ohashi; T Fukuda; A Kido; M Tsutsumi
Journal:  Jpn J Cancer Res       Date:  1995-12

9.  Dose-dependent induction of 8-hydroxyguanine and preneoplastic foci in rat liver by a food-derived carcinogen, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, at low dose levels.

Authors:  T Kato; R Hasegawa; D Nakae; M Hirose; M Yaono; L Cui; Y Kobayashi; Y Konishi; N Ito; T Shirai
Journal:  Jpn J Cancer Res       Date:  1996-02

10.  Relation of 8-hydroxydeoxyguanosine formation in rat kidney to lipid peroxidation, glutathione level and relative organ weight after a single administration of potassium bromate.

Authors:  K Sai; A Takagi; T Umemura; R Hasegawa; Y Kurokawa
Journal:  Jpn J Cancer Res       Date:  1991-02
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.