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Literature DB >> 21124306

Working on a chain: E3s ganging up for ubiquitylation.

Abstract

Substrate specificity in ubiquitylation is conferred by ubiquitin ligases (E3s). Now, several ways that E3s can interact to mediate ubiquitylation are illustrated for Ubr1 (a RING finger E3) and Ufd4 (a HECT domain E3), in Saccharomyces cerevisiae. These interactions and the related concept of E4 activity are discussed.

Entities: Gene Species

Mesh：

Substances：

Year: 2010 PMID： 21124306 DOI： 10.1038/ncb1210-1124

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

17 in total

1. A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly.

Authors: M Koegl; T Hoppe; S Schlenker; H D Ulrich; T U Mayer; S Jentsch
Journal: Cell Date: 1999-03-05 Impact factor: 41.582

Review 2. The ubiquitin system for protein degradation.

Authors: A Hershko; A Ciechanover
Journal: Annu Rev Biochem Date: 1992 Impact factor: 23.643

3. Autoregulation of an E2 enzyme by ubiquitin-chain assembly on its catalytic residue.

Authors: Tommer Ravid; Mark Hochstrasser
Journal: Nat Cell Biol Date: 2007-02-21 Impact factor: 28.824

4. Mechanistic insights into active site-associated polyubiquitination by the ubiquitin-conjugating enzyme Ube2g2.

Authors: Wei Li; Daqi Tu; Lianyun Li; Thomas Wollert; Rodolfo Ghirlando; Axel T Brunger; Yihong Ye
Journal: Proc Natl Acad Sci U S A Date: 2009-02-17 Impact factor: 11.205

5. Polyubiquitination by HECT E3s and the determinants of chain type specificity.

Authors: Hyung Cheol Kim; Jon M Huibregtse
Journal: Mol Cell Biol Date: 2009-04-13 Impact factor: 4.272

6. Physical association of ubiquitin ligases and the 26S proteasome.

Authors: Y Xie; A Varshavsky
Journal: Proc Natl Acad Sci U S A Date: 2000-03-14 Impact factor: 11.205

7. Liver cytochrome P450 3A ubiquitination in vivo by gp78/autocrine motility factor receptor and C terminus of Hsp70-interacting protein (CHIP) E3 ubiquitin ligases: physiological and pharmacological relevance.

Authors: Sung-Mi Kim; Poulomi Acharya; Juan C Engel; Maria Almira Correia
Journal: J Biol Chem Date: 2010-09-06 Impact factor: 5.157

8. UFD4 lacking the proteasome-binding region catalyses ubiquitination but is impaired in proteolysis.

Authors: Youming Xie; Alexander Varshavsky
Journal: Nat Cell Biol Date: 2002-12 Impact factor: 28.824

9. Two proteolytic pathways regulate DNA repair by cotargeting the Mgt1 alkylguanine transferase.

Authors: Cheol-Sang Hwang; Anna Shemorry; Alexander Varshavsky
Journal: Proc Natl Acad Sci U S A Date: 2009-01-21 Impact factor: 11.205

10. The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases.

Authors: Cheol-Sang Hwang; Anna Shemorry; Daniel Auerbach; Alexander Varshavsky
Journal: Nat Cell Biol Date: 2010-11-14 Impact factor: 28.824

13 in total

Review 1. The Role of Proteases in Hippocampal Synaptic Plasticity: Putting Together Small Pieces of a Complex Puzzle.

Authors: Ivan L Salazar; Margarida V Caldeira; Michele Curcio; Carlos B Duarte
Journal: Neurochem Res Date: 2015-11-07 Impact factor: 3.996

Review 2. The role of ubiquitination in tumorigenesis and targeted drug discovery.

Authors: Lu Deng; Tong Meng; Lei Chen; Wenyi Wei; Ping Wang
Journal: Signal Transduct Target Ther Date: 2020-02-29

3. Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates.

Authors: Henrike C Besche; Zhe Sha; Nikolay V Kukushkin; Andreas Peth; Eva-Maria Hock; Woong Kim; Steven Gygi; Juan A Gutierrez; Hua Liao; Lawrence Dick; Alfred L Goldberg
Journal: EMBO J Date: 2014-05-08 Impact factor: 11.598

Review 4. Archaeal proteasomes and sampylation.

Authors: Julie A Maupin-Furlow
Journal: Subcell Biochem Date: 2013

Review 5. Atypical ubiquitylation - the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages.

Authors: Yogesh Kulathu; David Komander
Journal: Nat Rev Mol Cell Biol Date: 2012-07-23 Impact factor: 94.444

6. Ubiquitin ligases of the N-end rule pathway: assessment of mutations in UBR1 that cause the Johanson-Blizzard syndrome.

Authors: Cheol-Sang Hwang; Maja Sukalo; Olga Batygin; Marie-Claude Addor; Han Brunner; Antonio Perez Aytes; Julia Mayerle; Hyun Kyu Song; Alexander Varshavsky; Martin Zenker
Journal: PLoS One Date: 2011-09-13 Impact factor: 3.240

7. Drosophila morgue associates with SkpA and polyubiquitin in vivo.

Authors: Ying Zhou; Yiqin Wang; Barbara A Schreader; John R Nambu
Journal: PLoS One Date: 2013-09-30 Impact factor: 3.240

8. Multiple regulation of Rad51-mediated homologous recombination by fission yeast Fbh1.

Authors: Yasuhiro Tsutsui; Yumiko Kurokawa; Kentaro Ito; Md Shahjahan P Siddique; Yumiko Kawano; Fumiaki Yamao; Hiroshi Iwasaki
Journal: PLoS Genet Date: 2014-08-28 Impact factor: 5.917

9. The ubiquitin ligase Huwe1 regulates the maintenance and lymphoid commitment of hematopoietic stem cells.

Authors: Bryan King; Francesco Boccalatte; Kelly Moran-Crusio; Elmar Wolf; Jingjing Wang; Clarisse Kayembe; Charalampos Lazaris; Xiaofeng Yu; Beatriz Aranda-Orgilles; Anna Lasorella; Iannis Aifantis
Journal: Nat Immunol Date: 2016-09-26 Impact factor: 25.606

10. A novel function of cIAP1 as a mediator of CHIP-driven eIF4E regulation.

Authors: Tae Woong Seo; Ji Sun Lee; Ye Na Choi; Dar Heum Jeong; Sun Kyung Lee; Soon Ji Yoo
Journal: Sci Rep Date: 2017-08-29 Impact factor: 4.379