BACKGROUND: Vitamin D deficiency has been associated with markers for allergy and asthma severity in children with asthma. However, its association with Chinese adult asthmatics has not been studied. OBJECTIVE: To examine whether vitamin D status is associated with lung function and total serum IgE in Chinese adults with newly diagnosed asthma. METHODS: We conducted a cross-sectional study including 435 Chinese patients aged >18 years with newly diagnosed asthma. Vitamin D status was assessed by measuring serum 25 hydroxyvitamin D (25OHD) concentrations. The primary outcomes included airflow limitation, as measured by the forced expiratory volume in 1 s (FEV(1)), FEV(1) % predicted, and FEV(1)/forced vital capacity (FVC), and serum total IgE concentration. RESULTS: Vitamin D deficiency was prevalent in Chinese adults with asthma, with 88.9% of the subjects having 25OHD <50 nmol/l. Serum 25OHD concentration was positively correlated with FEV(1) % predicted (p = 0.02, r = 0.12). After adjusting for age, sex, body mass index, smoking, month of blood collection, and symptom duration, we found significant positive associations between 25OHD concentrations and FEV(1) (in liters), FEV(1) % predicted, and FEV(1)/FVC (p for trend < 0.05 for all). The adjusted odds ratios for the highest versus the lowest 25OHD quartile were 0.50 (0.26-0.96) for FEV(1) <75% predicted and 0.44 (0.20-0.95) for FEV(1)/FVC% <0.75. There was no significant association between 25OHD concentrations and total IgE. CONCLUSIONS: Vitamin D deficiency was highly prevalent in Chinese asthma patients, and vitamin D status was associated with lung function.
BACKGROUND:Vitamin D deficiency has been associated with markers for allergy and asthma severity in children with asthma. However, its association with Chinese adult asthmatics has not been studied. OBJECTIVE: To examine whether vitamin D status is associated with lung function and total serum IgE in Chinese adults with newly diagnosed asthma. METHODS: We conducted a cross-sectional study including 435 Chinese patients aged >18 years with newly diagnosed asthma. Vitamin D status was assessed by measuring serum 25 hydroxyvitamin D (25OHD) concentrations. The primary outcomes included airflow limitation, as measured by the forced expiratory volume in 1 s (FEV(1)), FEV(1) % predicted, and FEV(1)/forced vital capacity (FVC), and serum total IgE concentration. RESULTS:Vitamin D deficiency was prevalent in Chinese adults with asthma, with 88.9% of the subjects having 25OHD <50 nmol/l. Serum 25OHD concentration was positively correlated with FEV(1) % predicted (p = 0.02, r = 0.12). After adjusting for age, sex, body mass index, smoking, month of blood collection, and symptom duration, we found significant positive associations between 25OHD concentrations and FEV(1) (in liters), FEV(1) % predicted, and FEV(1)/FVC (p for trend < 0.05 for all). The adjusted odds ratios for the highest versus the lowest 25OHD quartile were 0.50 (0.26-0.96) for FEV(1) <75% predicted and 0.44 (0.20-0.95) for FEV(1)/FVC% <0.75. There was no significant association between 25OHD concentrations and total IgE. CONCLUSIONS:Vitamin D deficiency was highly prevalent in Chinese asthmapatients, and vitamin D status was associated with lung function.
Authors: Benjamin A Raby; Ross Lazarus; Edwin K Silverman; Steven Lake; Christoph Lange; Mathias Wjst; Scott T Weiss Journal: Am J Respir Crit Care Med Date: 2004-07-28 Impact factor: 21.405
Authors: Emmanuel Xystrakis; Siddharth Kusumakar; Sandra Boswell; Emma Peek; Zoë Urry; David F Richards; Tonye Adikibi; Carol Pridgeon; Margaret Dallman; Tuck-Kay Loke; Douglas S Robinson; Franck J Barrat; Anne O'Garra; Paul Lavender; Tak H Lee; Christopher Corrigan; Catherine M Hawrylowicz Journal: J Clin Invest Date: 2005-12-08 Impact factor: 14.808
Authors: Daniel J Raiten; Fayrouz A Sakr Ashour; A Catharine Ross; Simin N Meydani; Harry D Dawson; Charles B Stephensen; Bernard J Brabin; Parminder S Suchdev; Ben van Ommen Journal: J Nutr Date: 2015-04-01 Impact factor: 4.798
Authors: Rodney D Britt; Arij Faksh; Elizabeth R Vogel; Michael A Thompson; Vivian Chu; Hitesh C Pandya; Yassine Amrani; Richard J Martin; Christina M Pabelick; Y S Prakash Journal: J Cell Physiol Date: 2015-06 Impact factor: 6.384
Authors: W Checkley; C L Robinson; L M Baumann; N N Hansel; K M Romero; S L Pollard; R A Wise; R H Gilman; E Mougey; J J Lima Journal: Clin Exp Allergy Date: 2015-01 Impact factor: 5.018