Literature DB >> 21123811

The role of JNK proteins in metabolism.

Sara N Vallerie1, Gökhan S Hotamisligil.   

Abstract

The stress-activated c-Jun amino-terminal kinase (JNK) plays a pivotal role in metabolic conditions such as obesity, insulin resistance, and type 2 diabetes. Intricate tissue-specific tweaking of JNK activity in preclinical models of metabolic diseases reveals a complex interplay among local and systemic effects on carbohydrate and lipid metabolism. Synthesis of these entangled effects illustrates that for JNK inhibitors to have therapeutic impact, they must function in multiple cell types to modulate JNK activity.

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Year:  2010        PMID： 21123811     DOI： 10.1126/scitranslmed.3001007

Source DB:  PubMed          Journal:  Sci Transl Med        ISSN： 1946-6234            Impact factor:   17.956


  46 in total

1.  High glucose-induced repression of RAR/RXR in cardiomyocytes is mediated through oxidative stress/JNK signaling.

Authors:  Amar B Singh; Rakeshwar S Guleria; Irina T Nizamutdinova; Kenneth M Baker; Jing Pan
Journal:  J Cell Physiol       Date:  2012-06       Impact factor: 6.384

Review 2.  CD36 genetics and the metabolic complications of obesity.

Authors:  Latisha Love-Gregory; Nada A Abumrad
Journal:  Curr Opin Clin Nutr Metab Care       Date:  2011-11       Impact factor: 4.294

3.  Jnk1 Deficiency in Hematopoietic Cells Suppresses Macrophage Apoptosis and Increases Atherosclerosis in Low-Density Lipoprotein Receptor Null Mice.

Authors:  Vladimir R Babaev; Michele Yeung; Ebru Erbay; Lei Ding; Youmin Zhang; James M May; Sergio Fazio; Gökhan S Hotamisligil; MacRae F Linton
Journal:  Arterioscler Thromb Vasc Biol       Date:  2016-04-21       Impact factor: 8.311

4.  A critical role for PKR complexes with TRBP in Immunometabolic regulation and eIF2α phosphorylation in obesity.

Authors:  Takahisa Nakamura; Ryan C Kunz; Cai Zhang; Taishi Kimura; Celvie L Yuan; Brenna Baccaro; Yuka Namiki; Steven P Gygi; Gökhan S Hotamisligil
Journal:  Cell Rep       Date:  2015-04-02       Impact factor: 9.423

Review 5.  Targeting inflammation in the treatment of type 2 diabetes: time to start.

Authors:  Marc Y Donath
Journal:  Nat Rev Drug Discov       Date:  2014-05-23       Impact factor: 84.694

Review 6.  Mechanisms of lipotoxicity in NAFLD and clinical implications.

Authors:  Samar H Ibrahim; Rohit Kohli; Gregory J Gores
Journal:  J Pediatr Gastroenterol Nutr       Date:  2011-08       Impact factor: 2.839

7.  ASK1 inhibition reduces cell death and hepatic fibrosis in an Nlrp3 mutant liver injury model.

Authors:  Susanne Schuster-Gaul; Lukas Jonathan Geisler; Matthew D McGeough; Casey D Johnson; Anna Zagorska; Li Li; Alexander Wree; Vivian Barry; Igor Mikaelian; Lily J Jih; Bettina G Papouchado; Grant Budas; Hal M Hoffman; Ariel E Feldstein
Journal:  JCI Insight       Date:  2020-01-30

8.  JNK signaling contributes to skeletal muscle wasting and protein turnover in pancreatic cancer cachexia.

Authors:  Scott E Mulder; Aneesha Dasgupta; Ryan J King; Jaime Abrego; Kuldeep S Attri; Divya Murthy; Surendra K Shukla; Pankaj K Singh
Journal:  Cancer Lett       Date:  2020-07-28       Impact factor: 8.679

Review 9.  The inflammation highway: metabolism accelerates inflammatory traffic in obesity.

Authors:  Amy R Johnson; J Justin Milner; Liza Makowski
Journal:  Immunol Rev       Date:  2012-09       Impact factor: 12.988

10.  Association between specific adipose tissue CD4+ T-cell populations and insulin resistance in obese individuals.

Authors:  Elisa Fabbrini; Marina Cella; Steve A McCartney; Anja Fuchs; Nada A Abumrad; Terri A Pietka; Zhouji Chen; Brian N Finck; Dong Ho Han; Faidon Magkos; Caterina Conte; David Bradley; Gemma Fraterrigo; J Christopher Eagon; Bruce W Patterson; Marco Colonna; Samuel Klein
Journal:  Gastroenterology       Date:  2013-04-15       Impact factor: 22.682
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