Literature DB >> 21123383

The adenovirus E1b55K/E4orf6 complex induces degradation of the Bloom helicase during infection.

Nicole I Orazio1, Colleen M Naeger, Jan Karlseder, Matthew D Weitzman.   

Abstract

The adenovirus (Ad) E1b55K and E4orf6 gene products assemble an E3 ubiquitin ligase complex that promotes degradation of cellular proteins. Among the known substrates are p53 and the Mre11-Rad50-Nbs1 (MRN) complex. Since members of the RecQ helicase family function together with MRN in genome maintenance, we investigated whether adenovirus affects RecQ proteins. We show that Bloom helicase (BLM) is degraded during adenovirus type 5 (Ad5) infection. BLM degradation is mediated by E1b55K/E4orf6 but is independent of MRN. We detected BLM localized at discrete foci around viral replication centers. These studies identify BLM as a new substrate for degradation by the adenovirus E1b55K/E4orf6 complex.

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Year:  2010        PMID： 21123383      PMCID： PMC3028918          DOI： 10.1128/JVI.02134-10

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  73 in total

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Authors:  S Zhong; P Hu; T Z Ye; R Stan; N A Ellis; P P Pandolfi
Journal:  Oncogene       Date:  1999-12-23       Impact factor: 9.867

4.  E1B 55-kilodalton oncoproteins of adenovirus types 5 and 12 inactivate and relocalize p53, but not p51 or p73, and cooperate with E4orf6 proteins to destabilize p53.

Authors:  S Wienzek; J Roth; M Dobbelstein
Journal:  J Virol       Date:  2000-01       Impact factor: 5.103

5.  Nuclear structure in normal and Bloom syndrome cells.

Authors:  V Yankiwski; R A Marciniak; L Guarente; N F Neff
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-09       Impact factor: 11.205

6.  Adenovirus E4 34k and E4 11k inhibit double strand break repair and are physically associated with the cellular DNA-dependent protein kinase.

Authors:  J Boyer; K Rohleder; G Ketner
Journal:  Virology       Date:  1999-10-25       Impact factor: 3.616

7.  The Bloom's syndrome gene product interacts with topoisomerase III.

Authors:  L Wu; S L Davies; P S North; H Goulaouic; J F Riou; H Turley; K C Gatter; I D Hickson
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8.  Retroviral expression of the NBS1 gene in cultured Nijmegen breakage syndrome cells restores normal radiation sensitivity and nuclear focus formation.

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Journal:  Mutagenesis       Date:  2000-05       Impact factor: 3.000

Review 9.  The MRN complex in double-strand break repair and telomere maintenance.

Authors:  Brandon J Lamarche; Nicole I Orazio; Matthew D Weitzman
Journal:  FEBS Lett       Date:  2010-07-24       Impact factor: 4.124

10.  Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells.

Authors:  F B Johnson; D B Lombard; N F Neff; M A Mastrangelo; W Dewolf; N A Ellis; R A Marciniak; Y Yin; R Jaenisch; L Guarente
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  49 in total

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2.  The α2 helix in the DNA ligase IV BRCT-1 domain is required for targeted degradation of ligase IV during adenovirus infection.

Authors:  Timra Gilson; Amy E Greer; Alessandro Vindigni; Gary Ketner; Leslyn A Hanakahi
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3.  Ubiquitin-dependent recruitment of the Bloom syndrome helicase upon replication stress is required to suppress homologous recombination.

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Review 4.  DNA virus replication compartments.

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Journal:  J Virol       Date:  2013-11-20       Impact factor: 5.103

5.  Analysis of the Cullin binding sites of the E4orf6 proteins of human adenovirus E3 ubiquitin ligases.

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Journal:  J Virol       Date:  2014-01-22       Impact factor: 5.103

6.  Proteomic analysis of ubiquitin-like posttranslational modifications induced by the adenovirus E4-ORF3 protein.

Authors:  Sook-Young Sohn; Rebecca G Bridges; Patrick Hearing
Journal:  J Virol       Date:  2014-11-19       Impact factor: 5.103

7.  Adenovirus E1B 55-Kilodalton Protein Targets SMARCAL1 for Degradation during Infection and Modulates Cellular DNA Replication.

Authors:  Reshma Nazeer; Fadi S I Qashqari; Abeer S Albalawi; Ann Liza Piberger; Maria Teresa Tilotta; Martin L Read; Siyuan Hu; Simon Davis; Christopher J McCabe; Eva Petermann; Andrew S Turnell
Journal:  J Virol       Date:  2019-06-14       Impact factor: 5.103

8.  The repression domain of the E1B 55-kilodalton protein participates in countering interferon-induced inhibition of adenovirus replication.

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Journal:  J Virol       Date:  2013-02-06       Impact factor: 5.103

9.  Role of E1B55K in E4orf6/E1B55K E3 ligase complexes formed by different human adenovirus serotypes.

Authors:  Chi Ying Cheng; Timra Gilson; Peter Wimmer; Sabrina Schreiner; Gary Ketner; Thomas Dobner; Philip E Branton; Paola Blanchette
Journal:  J Virol       Date:  2013-03-27       Impact factor: 5.103

10.  High Efficiency CRISPR/Cas9-mediated Gene Editing in Primary Human T-cells Using Mutant Adenoviral E4orf6/E1b55k "Helper" Proteins.

Authors:  Kamila S Gwiazda; Alexandra E Grier; Jaya Sahni; Stephen M Burleigh; Unja Martin; Julia G Yang; Nicholas A Popp; Michelle C Krutein; Iram F Khan; Kyle Jacoby; Michael C Jensen; David J Rawlings; Andrew M Scharenberg
Journal:  Mol Ther       Date:  2016-05-16       Impact factor: 11.454
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