OBJECTIVE: Abnormal perceptions and cognitions in schizophrenia might be related to abnormal resting states of the brain. Previous research found that a specific class (class D) of sub-second electroencephalography (EEG) microstates was shortened in schizophrenia. This shortening correlated with positive symptoms. We questioned if this reflected positive psychotic traits or present psychopathology. METHODS: Resting-state EEGs of frequently hallucinating patients, indicating on- and offset of hallucinations by button press, were analyzed. Microstate class D duration was related to spontaneous within-subject fluctuations of auditory hallucinations. RESULTS: Microstate D was significantly shorter in periods with hallucinations. CONCLUSIONS: Microstates of class D resemble topographies associated with error monitoring. Its premature termination may facilitate the misattribution of self-generated inner speech to external sources during hallucinations. SIGNIFICANCE: These results suggest that microstate D represents a biological state marker for hallucinatory experiences.
OBJECTIVE: Abnormal perceptions and cognitions in schizophrenia might be related to abnormal resting states of the brain. Previous research found that a specific class (class D) of sub-second electroencephalography (EEG) microstates was shortened in schizophrenia. This shortening correlated with positive symptoms. We questioned if this reflected positive psychotic traits or present psychopathology. METHODS: Resting-state EEGs of frequently hallucinatingpatients, indicating on- and offset of hallucinations by button press, were analyzed. Microstate class D duration was related to spontaneous within-subject fluctuations of auditory hallucinations. RESULTS: Microstate D was significantly shorter in periods with hallucinations. CONCLUSIONS: Microstates of class D resemble topographies associated with error monitoring. Its premature termination may facilitate the misattribution of self-generated inner speech to external sources during hallucinations. SIGNIFICANCE: These results suggest that microstate D represents a biological state marker for hallucinatory experiences.
Authors: Judith M Ford; Thomas Dierks; Derek J Fisher; Christoph S Herrmann; Daniela Hubl; Jochen Kindler; Thomas Koenig; Daniel H Mathalon; Kevin M Spencer; Werner Strik; Remko van Lutterveld Journal: Schizophr Bull Date: 2012-02-23 Impact factor: 9.306
Authors: Benjamin A Seitzman; Malene Abell; Samuel C Bartley; Molly A Erickson; Amanda R Bolbecker; William P Hetrick Journal: Neuroimage Date: 2016-10-11 Impact factor: 6.556
Authors: Anna Custo; Dimitri Van De Ville; William M Wells; Miralena I Tomescu; Denis Brunet; Christoph M Michel Journal: Brain Connect Date: 2017-11-17
Authors: Avinash Ramyead; Michael Kometer; Erich Studerus; Susan Koranyi; Sarah Ittig; Ute Gschwandtner; Peter Fuhr; Anita Riecher-Rössler Journal: Schizophr Bull Date: 2014-09-09 Impact factor: 9.306