L Wu1, L Zhu, W H Shi, B Yu, D Cai. 1. Department of General Surgery, Huashan Hospital of Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China.
Abstract
BACKGROUND AND OBJECTIVE: Zoledronate has been reported to inhibit the proliferation, adhesion and migration of vascular smooth muscle cells. In the present study, we assessed whether systemic and local delivery of zoledronate would be sufficient to prevent intimal hyperplasia. METHODS: Twenty-four male Sprague-Dawley rats were assigned into four groups: non-treated group, systemic zoledronate-treated group, local collagen-treated group and local zoledronate-treated group. All four groups underwent balloon injury to the right common carotid artery. The left uninjured carotid arteries of the non-treated group were considered as normal artery samples. Twenty-one days after arterial injury and treatment, the right and left common carotid arteries were fixed, sectioned, stained and measured by computer-aided image analysis. RESULTS: At 3 weeks, there was a 59% reduction of the intima/media area ratio in the systemic zoledronate-treated group compared with the non-treated group (P < 0.01). There was an 87% reduction of the intima/media area ratio in the local zoledronate-treated group compared with the local collagen-treated group (P < 0.01). CONCLUSIONS: Both systemic and local delivery of zoledronate correspond to a significant reduction in intimal hyperplasia seen at 3 weeks.
BACKGROUND AND OBJECTIVE:Zoledronate has been reported to inhibit the proliferation, adhesion and migration of vascular smooth muscle cells. In the present study, we assessed whether systemic and local delivery of zoledronate would be sufficient to prevent intimal hyperplasia. METHODS: Twenty-four male Sprague-Dawley rats were assigned into four groups: non-treated group, systemic zoledronate-treated group, local collagen-treated group and local zoledronate-treated group. All four groups underwent balloon injury to the right common carotid artery. The left uninjured carotid arteries of the non-treated group were considered as normal artery samples. Twenty-one days after arterial injury and treatment, the right and left common carotid arteries were fixed, sectioned, stained and measured by computer-aided image analysis. RESULTS: At 3 weeks, there was a 59% reduction of the intima/media area ratio in the systemic zoledronate-treated group compared with the non-treated group (P < 0.01). There was an 87% reduction of the intima/media area ratio in the local zoledronate-treated group compared with the local collagen-treated group (P < 0.01). CONCLUSIONS: Both systemic and local delivery of zoledronate correspond to a significant reduction in intimal hyperplasia seen at 3 weeks.
Authors: Ludwig D Orozco; Huiling Liu; Eddie Perkins; Daryl A Johnson; Betty B Chen; Fan Fan; Rodney C Baker; Richard J Roman Journal: J Pharmacol Exp Ther Date: 2013-05-08 Impact factor: 4.030
Authors: Hassan Albadawi; Mounir J Haurani; Rahmi Oklu; Jordan P Trubiano; Peter J Laub; Hyung-Jin Yoo; Michael T Watkins Journal: J Surg Res Date: 2012-11-08 Impact factor: 2.192
Authors: Yu-Chun Chang; Junlang Li; Gabriel Mirhaidari; Jacob Zbinden; Jenny Barker; Kevin Blum; James Reinhardt; Cameron Best; John Kelly; Toshihiro Shoji; Tai Yi; Christopher Breuer Journal: FASEB J Date: 2021-10 Impact factor: 5.834