PURPOSE: Apolipoprotein M (apoM) retards atherosclerosis development in murine models, and may be regulated by pathways involved in LDL metabolism. Proprotein convertase subtilisin-kexin type 9 (PCSK9) plays a key role in LDL receptor processing. We determined the extent to which plasma apoM is related to PCSK9 levels in subjects with varying degrees of obesity. METHODS: We sought correlations between plasma apoM and PCSK9, measured using recently developed ELISAs, in 79 non-diabetic subjects. RESULTS: ApoM and PCSK9 levels were both correlated positively with total cholesterol, non-HDL cholesterol, LDL cholesterol and apoB (P < 0.05 to P < 0.001). ApoM correlated positively with PCSK9 in lean individuals (n = 37, r = 0.337, P = 0.041), but not in overweight subjects (n = 32, r = 0.125, P = 0.50) and in obese subjects (n = 10, r = -0.055, P = 0.88). CONCLUSIONS: The PCSK9 pathway may contribute to plasma apoM regulation in humans. The influence of PCSK9 on circulating apoM appears to be modified by adiposity.
PURPOSE:Apolipoprotein M (apoM) retards atherosclerosis development in murine models, and may be regulated by pathways involved in LDL metabolism. Proprotein convertase subtilisin-kexin type 9 (PCSK9) plays a key role in LDL receptor processing. We determined the extent to which plasma apoM is related to PCSK9 levels in subjects with varying degrees of obesity. METHODS: We sought correlations between plasma apoM and PCSK9, measured using recently developed ELISAs, in 79 non-diabetic subjects. RESULTS:ApoM and PCSK9 levels were both correlated positively with total cholesterol, non-HDL cholesterol, LDL cholesterol and apoB (P < 0.05 to P < 0.001). ApoM correlated positively with PCSK9 in lean individuals (n = 37, r = 0.337, P = 0.041), but not in overweight subjects (n = 32, r = 0.125, P = 0.50) and in obese subjects (n = 10, r = -0.055, P = 0.88). CONCLUSIONS: The PCSK9 pathway may contribute to plasma apoM regulation in humans. The influence of PCSK9 on circulating apoM appears to be modified by adiposity.
Authors: Christina Christoffersen; Marianne Benn; Pernille M Christensen; Philip L S M Gordts; Anton J M Roebroek; Ruth Frikke-Schmidt; Anne Tybjaerg-Hansen; Björn Dahlbäck; Lars B Nielsen Journal: J Lipid Res Date: 2012-07-23 Impact factor: 5.922
Authors: Kristin M Burkart; Ani Manichaikul; Jemma B Wilk; Firas S Ahmed; Gregory L Burke; Paul Enright; Nadia N Hansel; Demondes Haynes; Susan R Heckbert; Eric A Hoffman; Joel D Kaufman; Jun Kurai; Laura Loehr; Stephanie J London; Yang Meng; George T O'Connor; Elizabeth Oelsner; Marcy Petrini; Tess D Pottinger; Charles A Powell; Susan Redline; Jerome I Rotter; Lewis J Smith; María Soler Artigas; Martin D Tobin; Michael Y Tsai; Karol Watson; Wendy White; Taylor R Young; Stephen S Rich; R Graham Barr Journal: Eur Respir J Date: 2013-07-30 Impact factor: 16.671