BACKGROUND AND AIMS: Patients with inflammatory bowel disease (IBD) who want to have children are anxious to receive medical treatment. The consensus regarding pregnancy has not been surveyed for male IBD patients. The present study was investigated opinions among male IBD patients about pregnancy, conception and neonatal outcomes for partners. METHODS: Subjects comprised 364 of 386 patients enrolled (94.3%). Subjects received a questionnaire regarding their opinions and thoughts about pregnancy. The course of partner's conceptions and presence of neonatal malformations was also surveyed. RESULTS: The rate of live births for partners of male IBD patients was 91.6% (219/239). Most patients with CD (29/33; 88%) had their children after surgery had been performed. The rate of expressing hopes to have a child tended to be higher for patients with UC (93/128; 73%) than for patients with CD (61/97; 63%; p=0.21). Furthermore, the rate of hesitation was significantly higher in CD patients (34/107; 32%) than in UC patients (38/188; 20%; p=0.03).Patients considered that safety of medication (51%) and maintenance of remission (41%) was more important than receiving no treatment for IBD (19%) when planning to conceive. Mesalamine and infliximab were more favorable at conception than sulfasalazine and immunomodulators. CONCLUSIONS: This is the first report to survey the thinking of male IBD patients regarding pregnancy. Most male IBD patients considered "maintaining remission" as important at conception. Our study provides important information for IBD patients and for the treating physician when planning to conceive.
BACKGROUND AND AIMS: Patients with inflammatory bowel disease (IBD) who want to have children are anxious to receive medical treatment. The consensus regarding pregnancy has not been surveyed for male IBDpatients. The present study was investigated opinions among male IBDpatients about pregnancy, conception and neonatal outcomes for partners. METHODS: Subjects comprised 364 of 386 patients enrolled (94.3%). Subjects received a questionnaire regarding their opinions and thoughts about pregnancy. The course of partner's conceptions and presence of neonatal malformations was also surveyed. RESULTS: The rate of live births for partners of male IBDpatients was 91.6% (219/239). Most patients with CD (29/33; 88%) had their children after surgery had been performed. The rate of expressing hopes to have a child tended to be higher for patients with UC (93/128; 73%) than for patients with CD (61/97; 63%; p=0.21). Furthermore, the rate of hesitation was significantly higher in CDpatients (34/107; 32%) than in UC patients (38/188; 20%; p=0.03).Patients considered that safety of medication (51%) and maintenance of remission (41%) was more important than receiving no treatment for IBD (19%) when planning to conceive. Mesalamine and infliximab were more favorable at conception than sulfasalazine and immunomodulators. CONCLUSIONS: This is the first report to survey the thinking of male IBDpatients regarding pregnancy. Most male IBDpatients considered "maintaining remission" as important at conception. Our study provides important information for IBDpatients and for the treating physician when planning to conceive.
Authors: Feiby L Nassan; Brent A Coull; Niels E Skakkebaek; Michelle A Williams; Ramace Dadd; Lidia Mínguez-Alarcón; Stephen A Krawetz; Elizabeth J Hait; Joshua R Korzenik; Alan C Moss; Jennifer B Ford; Russ Hauser Journal: Environ Int Date: 2016-08-26 Impact factor: 9.621
Authors: Stefano Palomba; Giuliana Sereni; Angela Falbo; Marina Beltrami; Silvia Lombardini; Maria Chiara Boni; Giovanni Fornaciari; Romano Sassatelli; Giovanni Battista La Sala Journal: World J Gastroenterol Date: 2014-06-21 Impact factor: 5.742
Authors: Luis Fernando Perez-Garcia; Esther Röder; Robbert J Goekoop; Johanna M W Hazes; Marc R Kok; Hieronymus T W Smeele; Ilja Tchetverikov; Annette H M van der Helm-van Mil; Jos H van der Kaap; Petra Kok; Bouwe P Krijthe; Radboud J E M Dolhain Journal: Ann Rheum Dis Date: 2021-08-09 Impact factor: 19.103