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Literature DB >> 2112250

Overexpression of Cu-Zn superoxide dismutase in Drosophila does not affect life-span.

Abstract

Aging and disease processes may be due to deleterious and irreversible changes produced by free radical reactions. The enzyme copper-zinc superoxide dismutase (Cu-Zn SOD; superoxide:superoxide oxidoreductase, EC 1.15.1.1) performs a protective function by scavenging superoxide radicals. The Cu-Zn SOD gene (Sod) cloned from Drosophila melanogaster was introduced via P element-mediated transformation into the germ line. Homozygous lines carrying additional copies of the Sod gene were recovered and characterized. Increases in Sod transcripts and enzyme activity were observed in the transformed lines, indicating that all of the sequence information required for gene expression is contained on the inserted gene fragment. The effects of additional SOD on oxygen free radical metabolism and longevity were investigated. Additional SOD did not markedly affect oxygen metabolism or longevity.

Entities: Chemical Gene Species

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Year: 1990 PMID： 2112250 PMCID： PMC54090 DOI： 10.1073/pnas.87.11.4270

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

33 in total

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34 in total

1. Expression of multiple copies of mitochondrially targeted catalase or genomic Mn superoxide dismutase transgenes does not extend the life span of Drosophila melanogaster.

Authors: Robin J Mockett; Barbara H Sohal; Rajindar S Sohal
Journal: Free Radic Biol Med Date: 2010-10-19 Impact factor: 7.376

2. Overexpression of glucose-6-phosphate dehydrogenase extends the life span of Drosophila melanogaster.

Authors: Susan K Legan; Igor Rebrin; Robin J Mockett; Svetlana N Radyuk; Vladimir I Klichko; Rajindar S Sohal; William C Orr
Journal: J Biol Chem Date: 2008-09-22 Impact factor: 5.157

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Authors: F Muller
Journal: J Am Aging Assoc Date: 2000-10

4. Overexpression of an antioxidant enzyme improves male mating performance after stress in a lek-mating fruit fly.

Authors: Nicholas M Teets; Vanessa S Dias; Bailey K Pierce; Marc F Schetelig; Alfred M Handler; Daniel A Hahn
Journal: Proc Biol Sci Date: 2019-06-12 Impact factor: 5.349

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Authors: Anne-Cécile V Bayne; Robin J Mockett; William C Orr; Rajindar S Sohal
Journal: Biochem J Date: 2005-10-15 Impact factor: 3.857

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Authors: Valentina A Shchedrina; Gerd Vorbrüggen; Byung Cheon Lee; Hwa-Young Kim; Hadise Kabil; Lawrence G Harshman; Vadim N Gladyshev
Journal: Mech Ageing Dev Date: 2009-05-03 Impact factor: 5.432

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Authors: Jingtao Sun; Donna Folk; Timothy J Bradley; John Tower
Journal: Genetics Date: 2002-06 Impact factor: 4.562

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Journal: Genetics Date: 1993-07 Impact factor: 4.562