BACKGROUND AND PURPOSE: Corpus callosum (CC) is frequently involved in multiple sclerosis (MS). We aimed to investigate the relations between CC microstructure integrity as measured by diffusion tensor imaging (DTI) in relapsing-remitting MS patients with low neurological disability in comparison with age-matched healthy subjects and further to identify correlations between DTI-CC parameters and clinical variables of MS disease activity. METHODS: CC volume was measured on 3.0T brain MRI by MS Analyze software. DTI metrics acquired along 31 independent directions were obtained and fractional anisotropy (FA), apparent diffusion coefficient (ADC), longitudinal (λ1) and transverse (λ 2, λ 3) diffusivities were measured in MS patients and healthy subjects. Disease activity was assessed by relapse rate and neurolgical disability by the Extended Disability Status Scale (EDSS). RESULTS: Thirty relapsing-remitting MS patients and 30 age- and sex-matched healthy subjects were studied. CC volume and DTI metrics differed significantly between MS patients and healthy subjects. In MS patients, all DTI parameters correlated with neurological disability. ADC, longitudinal and transverse diffusivity correlated with disease duration. ADC and the transverse diffusivity correlated with relapse rate. CONCLUSIONS: CC DTI parameters, especially ADC and transverse diffusivity correlated with disease variables especially with those associated with clinical activity.
BACKGROUND AND PURPOSE: Corpus callosum (CC) is frequently involved in multiple sclerosis (MS). We aimed to investigate the relations between CC microstructure integrity as measured by diffusion tensor imaging (DTI) in relapsing-remitting MSpatients with low neurological disability in comparison with age-matched healthy subjects and further to identify correlations between DTI-CC parameters and clinical variables of MS disease activity. METHODS: CC volume was measured on 3.0T brain MRI by MS Analyze software. DTI metrics acquired along 31 independent directions were obtained and fractional anisotropy (FA), apparent diffusion coefficient (ADC), longitudinal (λ1) and transverse (λ 2, λ 3) diffusivities were measured in MSpatients and healthy subjects. Disease activity was assessed by relapse rate and neurolgical disability by the Extended Disability Status Scale (EDSS). RESULTS: Thirty relapsing-remitting MSpatients and 30 age- and sex-matched healthy subjects were studied. CC volume and DTI metrics differed significantly between MSpatients and healthy subjects. In MSpatients, all DTI parameters correlated with neurological disability. ADC, longitudinal and transverse diffusivity correlated with disease duration. ADC and the transverse diffusivity correlated with relapse rate. CONCLUSIONS: CC DTI parameters, especially ADC and transverse diffusivity correlated with disease variables especially with those associated with clinical activity.
Authors: Yongxia Zhou; M Milham; X-N Zuo; C Kelly; H Jaggi; J Herbert; R I Grossman; Y Ge Journal: AJNR Am J Neuroradiol Date: 2013-01-24 Impact factor: 3.825
Authors: Tomas Kalincik; Manuela Vaneckova; Michaela Tyblova; Jan Krasensky; Zdenek Seidl; Eva Havrdova; Dana Horakova Journal: PLoS One Date: 2012-11-15 Impact factor: 3.240
Authors: Renuka Natarajan; Sanna Hagman; Xingchen Wu; Ullamari Hakulinen; Minna Raunio; Mika Helminen; Maija Rossi; Prasun Dastidar; Irina Elovaara Journal: Mult Scler Int Date: 2013-12-17
Authors: Paola Tortorella; Maria Marcella Laganà; Marina Saresella; Eleonora Tavazzi; Maria Giulia Preti; Cristian Ricci; Francesca Baglio; Ivana Marventano; Federica Piancone; Giuseppe Baselli; Pietro Cecconi; Domenico Caputo; Mario Clerici; Marco Rovaris Journal: Biomed Res Int Date: 2014-04-09 Impact factor: 3.411