Literature DB >> 21118696

Alpha-1-adrenergic receptors: targets for agonist drugs to treat heart failure.

Brian C Jensen1, Timothy D O'Connell, Paul C Simpson.   

Abstract

Evidence from cell, animal, and human studies demonstrates that α1-adrenergic receptors mediate adaptive and protective effects in the heart. These effects may be particularly important in chronic heart failure, when catecholamine levels are elevated and β-adrenergic receptors are down-regulated and dysfunctional. This review summarizes these data and proposes that selectively activating α1-adrenergic receptors in the heart might represent a novel and effective way to treat heart failure. This article is part of a special issue entitled "Key Signaling Molecules in Hypertrophy and Heart Failure." Published by Elsevier Ltd.

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Year:  2010        PMID： 21118696      PMCID： PMC3085055          DOI： 10.1016/j.yjmcc.2010.11.014

Source DB:  PubMed          Journal:  J Mol Cell Cardiol        ISSN： 0022-2828            Impact factor:   5.000


  208 in total

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Journal:  Circ Res       Date:  1986-09       Impact factor: 17.367

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4.  β-myosin heavy chain is induced by pressure overload in a minor subpopulation of smaller mouse cardiac myocytes.

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Journal:  Am J Physiol Heart Circ Physiol       Date:  2004-04-22       Impact factor: 4.733

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Journal:  Nature       Date:  1995-04-13       Impact factor: 49.962

8.  Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha 1 adrenergic response.

Authors:  P Simpson
Journal:  J Clin Invest       Date:  1983-08       Impact factor: 14.808

9.  Alpha-skeletal actin is associated with increased contractility in the mouse heart.

Authors:  T E Hewett; I L Grupp; G Grupp; J Robbins
Journal:  Circ Res       Date:  1994-04       Impact factor: 17.367

Review 10.  What is the role of beta-adrenergic signaling in heart failure?

Authors:  Martin J Lohse; Stefan Engelhardt; Thomas Eschenhagen
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Review 6.  Adrenoceptor regulation of the mechanistic target of rapamycin in muscle and adipose tissue.

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9.  Adrenergic α₁ receptor activation is sufficient, but not necessary for phrenic long-term facilitation.

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